| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-29 12:14:00 | stimulation of Epac proteins could have either beneficial or deleterious effects depending on the steady-state Ca(2+) levels at which the myocyte is functioning, favoring the prevailing mechanism of sarcoplasmic reticulum Ca(2+) handling (uptake vs. leak) in the different situations. | 29037982 |
| 2019-03-30 10:07:00 | Activation of Epac1-Akt signaling pathway. | 30551377 |
| 2018-12-29 10:40:00 | Epac1/Epac2 and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy. | 30225708 |
| 2018-08-04 10:52:00 | Epac and its downstream pathway may be a novel target for treating cardiac dysfunction in endotoxemia. | 27995459 |
| 2017-06-24 11:42:00 | Rap guanine nucleotide exchange factors Epac1 and Epac2 induces the phosphorylation of extracellular signal-regulated kinases ERK1/2 in pituitary tumor GH3 cells. | 28216156 |
| Type | IDs |
|---|---|
| Synonymous | Epac |
| Gene |
UniProtKB-ID:
RPGF3_RAT,
Q3B7C8_RAT,
A0A0G2JWN8_RAT
UniprotKB:
Q9Z1C8,
Q3B7C8,
A0A0G2JWN8
UniParc:
UPI000176165D,
UPI00005D39A2,
UPI00000E6109,
UPI0001B7AE14
EMBL:
AABR03056109,
AC121206,
CH474035,
U78167,
BC107667,
AABR03058672
Ensembl:
ENSRNOG00000059961
KO:
rno:59326
|
| Nucleutide sequences |
EMBL-CDS:
AAD12739.1,
AAI07668.1,
EDL87101.1
Gene_ORFName:
rCG_50571
Ensembl_TRS:
ENSRNOT00000078644,
ENSRNOT00000083182
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000072633,
ENSRNOP00000069952
RefSeq:
XP_008764001.1,
XP_008764002.1,
XP_008764000.1,
NP_067722.2,
XP_006242414.1
|
| Others |
UniRef100:
UniRef100_Q3B7C8,
UniRef100_Q9Z1C8,
UniRef100_A0A0G2JWN8
UniRef90:
UniRef90_Q9Z1C8
UniRef50:
UniRef50_Q9Z1C8
UniGene:
Rn.42899
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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