| Type | Description |
|---|---|
| Definition | single Ig and TIR domain containing |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:29:00 | The anti-inflammatory IL-37/SIGIRR axis is functionally compromised in HIV infection. | 31149943 |
| 2020-06-27 12:29:00 | Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR | 32210474 |
| 2019-08-03 11:10:00 | Specificity protein 1 modulates TGFbeta1/Smad signaling and negatively regulates SIGIRR protein production by macrophages after substance P stimulation. | 29558695 |
| 2018-07-07 11:58:00 | SIGIRR is both a negative regulator of TLR4 and a positive regulator of TLR7/8. | 28869081 |
| 2018-04-28 11:56:00 | Our results indicate that high IL-1R8 expression acts as a novel immunomodulatory mechanism leading to dysregulated immunity with important implications for breast cancer immunotherapy. | 28533483 |
| Type | IDs |
|---|---|
| Synonymous | IL-1R8, TIR8 |
| Gene |
UniProtKB-ID:
SIGIR_HUMAN,
C9JFX4_HUMAN
UniprotKB:
Q6IA17,
C9JFX4
UniParc:
UPI000049DD22,
UPI0001E5E84D,
UPI0000D6256C
EMBL:
AY358342,
AK025099,
BC025953,
AC138230,
BC003591,
BC106007,
CR457338
Ensembl:
ENSG00000185187
KO:
hsa:59307
|
| Nucleutide sequences |
EMBL-CDS:
AAI06008.1,
AAH25953.1,
CAG33619.1,
AAH03591.1,
BAB15066.1,
AAQ88708.1
Gene_ORFName:
UNQ301/PRO342
Ensembl_TRS:
ENST00000397632,
ENST00000332725,
ENST00000431843,
ENST00000531205
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000403104,
ENSP00000333656,
ENSP00000380756,
ENSP00000433022
RefSeq:
XP_005253102.1,
NP_001128526.1,
XP_005253103.1,
XP_016873588.1,
XP_016873589.1,
NP_068577.2,
XP_005253101.1,
NP_001128525.1,
XP_005253105.1
|
| Others |
UniRef100:
UniRef100_Q6IA17,
UniRef100_C9JFX4
UniRef90:
UniRef90_Q6IA17,
UniRef90_Q6IA17-2
UniRef50:
UniRef50_Q6IA17-2,
UniRef50_Q6IA17
UniGene:
Hs.501624
CCDS:
CCDS31325.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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