| Type | Description |
|---|---|
| Definition | nicastrin |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:16:00 | Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression. | 31884525 |
| 2020-07-04 12:21:00 | The missense mutation severely limits the glycosylation of NCSTN to its mature form and impairs the integrity of the gamma-secretase complex as well as its catalytic activity toward its substrate Notch, a critical regulator of B cell and T cell development. Essential requirement for nicastrin in marginal zone and B-1 B cell development. | 32071239 |
| 2016-12-17 11:32:00 | mice defective of the nicastrin subunit of gamma-secretase in oligodendrocytes have hypomyelination in the central nervous system. | 27008863 |
| 2016-11-19 10:53:00 | The results of this study showed that elevated p-tau levels in NCT cKO mice and have demonstrated that changes on p-tau were likely caused by enhanced activity of CDK5 but not GSK3beta. | 26804055 |
| 2016-10-01 10:54:00 | PS1(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation. | 26608390 |
| Type | IDs |
|---|---|
| Synonymous | 9430068N19Rik, AA727311, Aph2, D1Dau13e, Kiaa0253, Nct, mKIAA0253 |
| Gene |
UniProtKB-ID:
NICA_MOUSE
UniprotKB:
P57716
UniParc:
UPI0000020D41
EMBL:
AC158930,
AF240469,
BC019998
Ensembl:
ENSMUSG00000003458
KO:
mmu:59287
|
| Nucleutide sequences |
EMBL-CDS:
AAG11413.1,
AAH19998.1
Ensembl_TRS:
ENSMUST00000003550
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003550
RefSeq:
XP_017177361.1,
NP_067620.3,
XP_006497015.1
|
| Others |
UniRef100:
UniRef100_P57716
UniRef90:
UniRef90_P57716
UniRef50:
UniRef50_Q92542
UniGene:
Mm.218203
CCDS:
CCDS15507.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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