| Type | Description |
|---|---|
| Definition | Rap1 GTPase-GDP dissociation stimulator 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:44:00 | Targeting SmgGDS splicing to lower the protein isoform ratio is effective to inhibit the malignant phenotype generated by small GTPases. | 32019878 |
| 2020-03-21 11:03:00 | The competitive binding affinities of the small GTPase for SmgGDS-607 and FTase dictate the extent of this inhibition. SmgGDS-607 increases the rate of farnesylation of HRas by enhancing product release from FTase. | 31197034 |
| 2019-04-13 10:07:00 | SmgGDS-607 completely inhibits RhoA prenylation catalyzed by protein geranylgeranyltransferase I (GGTase-I) in an in vitro radiolabel incorporation assay. SmgGDS-607 inhibits prenylation by binding to and blocking access to the C-terminal tail of the small GTPase (substrate sequestration mechanism) rather than via inhibition of the prenyltransferase activity. | 29940100 |
| 2018-10-13 11:28:00 | Study reveals a cryptic pocket by which SmgGDS-558 accommodates RhoA prenylation, loosening the structure of Rho when it interacts with SmgGDS, which may enable drug development strategies for targeting SmgGDS and small GTPases. | 30190425 |
| 2017-12-23 13:05:00 | a novel nuclear role for SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression and tumorigenesis. | 28806394 |
| Type | IDs |
|---|---|
| Synonymous | GDS1, SmgGDS |
| Gene |
UniProtKB-ID:
GDS1_HUMAN,
Q6U7G8_HUMAN,
B3KNU0_HUMAN
UniprotKB:
P52306,
Q6U7G8,
B3KNU0
UniParc:
UPI00015A355B,
UPI000049DFE5,
UPI000056F20E,
UPI00001D629D,
UPI000053F601,
UPI000004A01F,
UPI000020B1F1,
UPI0000371610
EMBL:
AC058823,
BC001816,
X63465,
AY376900,
BC098334,
AC078961,
BC099708,
AF237413,
BC001851,
AK055032,
AF215923,
CH471057,
BT006837,
BC098269,
BC099845,
AC019077
Ensembl:
ENSG00000138698
KO:
hsa:5910
|
| Nucleutide sequences |
EMBL-CDS:
EAX06069.1,
AAH99708.1,
AAP35483.1,
AAH99845.1,
AAH98269.1,
EAX06071.1,
AAH01816.1,
CAA45067.1,
AAF32290.1,
AAH01851.2,
AAH98334.1,
AAF43211.1,
AAQ85126.1,
BAG51452.1
Ensembl_TRS:
ENST00000408927,
ENST00000264572,
ENST00000453712,
ENST00000339360,
ENST00000408900,
ENST00000380158
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000340454,
ENSP00000369503,
ENSP00000264572,
ENSP00000386223,
ENSP00000407157,
ENSP00000386153
RefSeq:
XP_024309944.1,
XP_024309933.1,
XP_024309942.1,
XP_024309937.1,
XP_024309938.1,
XP_024309939.1,
XP_024309940.1,
XP_024309936.1,
NP_001093899.1,
NP_001093900.1,
XP_024309932.1,
NP_001093898.1,
XP_024309941.1,
XP_024309934.1,
NP_066982.3,
NP_001093896.1,
NP_001093897.1,
XP_024309935.1,
XP_024309943.1
|
| Others |
UniRef100:
UniRef100_P52306,
UniRef100_B3KNU0,
UniRef100_Q6U7G8
UniRef90:
UniRef90_P52306-6,
UniRef90_P52306
UniRef50:
UniRef50_P52306
UniGene:
Hs.132858
CCDS:
CCDS47105.1,
CCDS47106.1,
CCDS43254.1,
CCDS47107.1,
CCDS43253.1,
CCDS47108.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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