| Type | Description |
|---|---|
| Definition | RAP1 GTPase activating protein |
| Date | Results | Publications |
|---|---|---|
| 2018-12-01 12:03:00 | This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS | 30144784 |
| 2018-10-20 12:08:00 | Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer. | 29758923 |
| 2017-08-05 10:11:00 | results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity | 27612188 |
| 2017-06-24 11:39:00 | Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC). | 28196746 |
| 2015-08-01 10:32:00 | Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo. | 25329897 |
| Type | IDs |
|---|---|
| Synonymous | RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP |
| Gene |
UniProtKB-ID:
RPGP1_HUMAN,
A0A024RAB5_HUMAN,
X6R8W7_HUMAN
UniprotKB:
P47736,
A0A024RAB5,
X6R8W7
UniParc:
UPI000046FFB8,
UPI0002A47535,
UPI0000EE7109,
UPI000153C066,
UPI000046FFB3
EMBL:
AB007943,
M64788,
BC054490,
AB003930,
CH471134,
AL359815
Ensembl:
ENSG00000076864
KO:
hsa:5909
|
| Nucleutide sequences |
EMBL-CDS:
AAA60252.1,
EAW94981.1,
BAA83674.1,
AAH54490.1,
EAW94980.1,
BAA32319.3,
EAW94986.1,
EAW94982.1,
EAW94985.1
Gene_ORFName:
hCG_37586
Ensembl_TRS:
ENST00000542643,
ENST00000495204,
ENST00000374765,
ENST00000374763
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000441661,
ENSP00000363897,
ENSP00000434033,
ENSP00000363895
RefSeq:
NP_001375222.1,
NP_001337457.1,
NP_001375223.1,
NP_001375220.1,
NP_001375153.1,
NP_001375188.1,
NP_001375196.1,
NP_001375198.1,
NP_001375141.1,
NP_001375147.1,
NP_001375156.1,
NP_001375136.1,
NP_001375140.1,
NP_001375216.1,
NP_001375151.1,
NP_001375129.1,
NP_001375176.1,
NP_001375133.1,
NP_001375130.1,
NP_001375212.1,
NP_001317312.1,
NP_001375192.1,
NP_001375143.1,
NP_001375168.1,
NP_001375146.1,
NP_001375219.1,
NP_001139130.1,
NP_001337455.1,
NP_001375134.1,
NP_002876.2,
NP_001375187.1,
NP_001375132.1,
NP_001375172.1,
NP_001337456.1,
NP_001375225.1,
NP_001139129.1,
NP_001375159.1,
NP_001375184.1,
NP_001375199.1,
NP_001375158.1,
NP_001375137.1,
NP_001375145.1,
NP_001375179.1,
NP_001375152.1,
NP_001375224.1,
NP_001375154.1,
NP_001375139.1,
NP_001375149.1,
NP_001375131.1,
NP_001337453.1,
NP_001375213.1,
NP_001375155.1,
NP_001375178.1,
NP_001375135.1,
NP_001337454.1,
NP_001375205.1,
NP_001375208.1,
NP_001375171.1,
NP_001375157.1,
NP_001375181.1,
NP_001375162.1,
NP_001375173.1,
NP_001375218.1,
NP_001375217.1,
NP_001375150.1,
NP_001375144.1,
NP_001375169.1,
NP_001375142.1,
NP_001375165.1,
NP_001375163.1,
NP_001375180.1,
NP_001375138.1,
NP_001375167.1,
NP_001375166.1,
NP_001375182.1,
NP_001375195.1,
NP_001375175.1,
NP_001375164.1,
NP_001375148.1,
NP_001375211.1,
NP_001375209.1,
NP_001375221.1,
NP_001375215.1,
NP_001375160.1,
NP_001375214.1,
NP_001375210.1,
NP_001375185.1,
NP_001375183.1,
NP_001375177.1,
NP_001375170.1,
NP_001375202.1,
NP_001375193.1,
NP_001375190.1,
NP_001375174.1
|
| Others |
UniRef100:
UniRef100_P47736,
UniRef100_X6R8W7
UniRef90:
UniRef90_P47736,
UniRef90_X6R8W7
UniRef50:
UniRef50_A2ALS5,
UniRef50_P47736
UniGene:
Hs.148178
CCDS:
CCDS53276.1,
CCDS218.1,
CCDS53277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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