| Type | Description |
|---|---|
| Definition | basic helix-loop-helix family, member e22 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-12 12:07:00 | Bhlhb5 is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus during development. Mice lacking Bhlhb5 had a diminished number of neurons. A Bhlhb5::flpo allele also genetically labels numerous other regions of the nervous system processing sensory input, including the dorsal horn, the retina, and the nucleus of the lateral olfactory tract. | 27151208 |
| 2015-02-21 11:38:00 | hypothesis that neuropathic itch in BHLHB5-deficient animals can be treated by restoring inhibitory controls through spinal cord transplantation and integration of precursors of inhibitory interneurons derived from embryonic medial ganglionic eminence | 25003193 |
| 2014-09-20 12:17:00 | Bhlhb5 is broadly expressed throughout retinogenesis, and is required for the subtype development of amacrine and bipolar cells. | 24123365 |
| 2012-07-21 11:25:00 | These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11. | 22284184 |
| 2010-04-19 11:29:00 | Atonal-related transcription factor Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritis, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch. | 20346763 |
| Type | IDs |
|---|---|
| Synonymous | Beta3, Beta3a, Bhlhb5 |
| Gene |
UniProtKB-ID:
BHE22_MOUSE,
A0A0R4J056_MOUSE
UniprotKB:
Q8C6A8,
A0A0R4J056
UniParc:
UPI0000023CE4,
UPI00000E9B74
EMBL:
AF218865,
AK076228,
AC100500,
BC053007
Ensembl:
ENSMUSG00000025128
KO:
mmu:59058
|
| Nucleutide sequences |
EMBL-CDS:
AAH53007.1,
AAF32324.1,
BAC36262.1
Ensembl_TRS:
ENSMUST00000026120
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026120
RefSeq:
NP_067535.3
|
| Others |
UniRef100:
UniRef100_A0A0R4J056,
UniRef100_Q8C6A8
UniRef90:
UniRef90_Q8C6A8
UniRef50:
UniRef50_Q8C6A8
UniGene:
Mm.149938
CCDS:
CCDS17253.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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