| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 11:30:00 | T cell-specific deletion of the gene encoding the deubiquitinase POH1 compromised the development of mature T cells, especially CD4(+)Foxp3(+) Treg cells. Moreover, POH1 deficiency significantly attenuated the transition of CD25(+) Treg cell precursors into Foxp3(+) Treg cells accompanied by downregulation of interleukin 2 signaling. | 30038387 |
| 2019-01-05 12:08:00 | Study thereby reveals that POH1-mediated deubiquitination of pro-IL-1beta is an important regulatory event that restrains inflammatory responses for the maintenance of immune homeostasis. | 30315153 |
| 2016-05-21 11:41:00 | Conditional knockout of Poh1 alleles results in reduced E2F1 expression in primary mouse liver cells. | 26510456 |
| 2010-06-28 11:17:00 | These results identify a novel mechanism of Mitf regulation in osteoclasts by POH1. | 20058232 |
| Type | IDs |
|---|---|
| Synonymous | 2610312C03Rik, 3200001M20Rik, AA986732, Pad1, Poh1, rpm11 |
| Gene |
UniProtKB-ID:
PSDE_MOUSE
UniprotKB:
O35593
UniParc:
UPI0000027819
EMBL:
AK151104,
BC003742,
AK151733,
AK012013,
Y13071
Ensembl:
ENSMUSG00000026914
KO:
mmu:59029
|
| Nucleutide sequences |
EMBL-CDS:
CAA73514.1,
BAE30648.1,
BAE30114.1,
BAB27974.1,
AAH03742.1
Ensembl_TRS:
ENSMUST00000028278
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028278
RefSeq:
NP_067501.2
|
| Others |
UniRef100:
UniRef100_O00487
UniRef90:
UniRef90_O00487
UniRef50:
UniRef50_O00487
UniGene:
Mm.218198
CCDS:
CCDS38127.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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