| Type | Description |
|---|---|
| Definition | protein inhibitor of activated STAT 4 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-27 11:14:00 | study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses | 28970247 |
| 2018-05-19 11:17:00 | PIAS4 mediated SIRT1 repression led to SMAD3 hyperacetylation and enhanced SMAD3 binding to fibrogenic gene promoters and PIAS4 promoted hepatic stellate cells activation in a SIRT1-dependent manner in vitro. | 27323886 |
| 2018-01-13 12:39:00 | Findings indicate that protein inhibitor of activated 4 (PIAS4) mediated SIRT1 repression in response to nutrient surplus contributes to the pathogenesis of Nonalcoholic Steatohepatitis (NASH). | 27285989 |
| 2017-07-22 11:30:00 | new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4. | 27162139 |
| 2014-04-26 12:59:00 | SREBP1c sumoylation by PIASy. | 24379443 |
| Type | IDs |
|---|---|
| Synonymous | PIASY, Pias-gamma, Piasg |
| Gene |
UniProtKB-ID:
PIAS4_MOUSE,
Q3ULQ6_MOUSE
UniprotKB:
Q9JM05,
Q3ULQ6
UniParc:
UPI0000020E55
EMBL:
BC025159,
AF109174,
AK145367
Ensembl:
ENSMUSG00000004934
KO:
mmu:59004
|
| Nucleutide sequences |
EMBL-CDS:
AAH25159.1,
AAF72040.1,
BAE26392.1
Ensembl_TRS:
ENSMUST00000005064
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000005064
RefSeq:
NP_067476.2
|
| Others |
UniRef100:
UniRef100_Q9JM05
UniRef90:
UniRef90_Q9JM05
UniRef50:
UniRef50_Q9JM05
UniGene:
Mm.34428
CCDS:
CCDS35992.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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