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5890 RAD51B

5890

RAD51B

RAD51 paralog B

protein-coding

Homo sapiens

基因描述

Type Description
Definition RAD51 paralog B

研究结论

Date Results Publications
2020-09-12 16:03:00 Sequential role of RAD51 paralog complexes in replication fork remodeling and restart. 32669601
2020-02-01 11:12:00 Here we provide three coherent sets of isogenic mutants, both in transformed and non-transformed human cells. Importantly, using these mutant lines, we report the unanticipated result that RAD51B has a less crucial role in homologous recombination than the other four paralogs, and find that all RAD51 paralogs are critically important for early functions during homologous recombination 31584931
2018-12-01 12:26:00 We successfully identified a common variant, rs911263, as being significantly associated with the disease status . In addition, this SNP was shown to be related to erosion, a clinical assessment of disease severity in RA (P = 2.89 x 10(-5), OR = 0.52). These findings shed light on the role of RAD51B in the onset and severity of Rheumatoid arthritis (RA). 28361912
2018-03-03 11:45:00 hypermethylation of homologous recombination DNA repair genes including RAD51B and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix. 27683114
2017-11-18 12:51:00 our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention. 27334422

名称对应

Type IDs
Synonymous R51H2, RAD51L1, REC2
Gene
UniProtKB-ID: RA51B_HUMAN, A0A024R656_HUMAN, C9JYJ0_HUMAN
UniprotKB: O15315, A0A024R656, C9JYJ0
UniParc: UPI000000CC45, UPI000002B205, UPI0000133006, UPI0000073AB0, UPI0001B79095, UPI00001FD744
EMBL: BC030219, AL121595, DQ160197, KF455920, U84138, AY138858, U92074, CR536560, Y15571, BX248766, CH471061, KF455917, AL133370, AY138857, BX248061, KC877523, BX161515, KF455919, AC004518, AY138859
Ensembl: ENSG00000182185
KO: hsa:5890
Nucleutide sequences
EMBL-CDS: AAC39723.1, AAZ85144.1, CAA75680.1, AAH30219.1, AAC32425.1, CAD61950.1, AAN60543.1, CAG38797.1, EAW80957.1, AAN60544.1, CAD62357.1, AAB63358.1, CAD66573.1, AAC32426.1, AAN60542.1, EAW80958.1
Gene_ORFName: hCG_2036537
Ensembl_TRS: ENST00000471583, ENST00000488612, ENST00000487270, ENST00000487861
Protein sequencees
Ensembl_PRO: ENSP00000418859, ENSP00000419471, ENSP00000420061, ENSP00000419881
RefSeq: NP_001308750.1, NP_001308747.1, NP_002868.1, NP_001308741.1, NP_001308738.1, NP_001308743.1, NP_001308748.1, NP_001308744.1, NP_598193.2, NP_001308739.1, NP_001308746.1, NP_598194.1
Others
UniRef100: UniRef100_C9JYJ0, UniRef100_A0A024R656, UniRef100_O15315
UniRef90: UniRef90_O15315, UniRef90_O15315-4, UniRef90_O15315-2
UniRef50: UniRef50_O15315-4, UniRef50_O15315
UniGene: Hs.172587
CCDS: CCDS9789.1, CCDS9790.1

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