| Type | Description |
|---|---|
| Definition | RAD51 paralog C |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:43:00 | A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect. | 31782267 |
| 2021-01-02 12:51:00 | BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases. | 32359370 |
| 2020-09-12 16:03:00 | Sequential role of RAD51 paralog complexes in replication fork remodeling and restart. | 32669601 |
| 2020-06-13 12:39:00 | This study provides evidence that germline loss-of-function variants of RAD51C are associated with hereditary breast cancer, particularly triple-negative type. RAD51C-null breast cancers possess similar genomic and clinical features to BRCA1-null cancers and may also be vulnerable to DNA double-strand break inducing chemotherapies and poly ADP-ribose polymerase inhibitors. | 30949688 |
| 2020-06-06 13:57:00 | Evidence that RAD51C-ALKBH3 interaction stimulates ALKBH3-mediated repair of methyl-adduct located within 3'-tailed DNA, which serves as a substrate for the RAD51 recombinase. The lack of RAD51C-ALKBH3 interaction affects ALKBH3 function in vitro and in vivo. | 31642493 |
| Type | IDs |
|---|---|
| Synonymous | BROVCA3, FANCO, R51H3, RAD51L2 |
| Gene |
UniProtKB-ID:
RA51C_HUMAN
UniprotKB:
O43502
UniParc:
UPI0000133007,
UPI000006DB00
EMBL:
CH471109,
AY623112,
BC107753,
AC011195,
AF029670,
AF029669,
AC025521
Ensembl:
ENSG00000108384
KO:
hsa:5889
|
| Nucleutide sequences |
EMBL-CDS:
AAC39604.1,
AAC39605.1,
EAW94432.1,
AAI07754.1,
AAT38108.1
Ensembl_TRS:
ENST00000421782,
ENST00000337432
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000336701,
ENSP00000391450
RefSeq:
XP_011523395.1,
XP_016880405.1,
XP_006722068.1,
NP_478123.1,
XP_006722064.1,
XP_016880404.1,
XP_006722065.1,
XP_016880403.1,
XP_011523394.1,
XP_006722067.1,
XP_016880408.1,
NP_002867.1,
XP_016880407.1,
XP_016880406.1,
XP_011523396.1
|
| Others |
UniRef100:
UniRef100_O43502
UniRef90:
UniRef90_O43502
UniRef50:
UniRef50_O43502
UniGene:
Hs.412587
CCDS:
CCDS45745.1,
CCDS11611.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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