| Type | Description |
|---|---|
| Definition | cysteinyl leukotriene receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 12:36:00 | these findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis. | 29412178 |
| 2019-06-22 10:59:00 | Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption. | 30183378 |
| 2018-11-03 11:53:00 | Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption. | 29916540 |
| 2018-03-17 11:09:00 | The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors. | 28410235 |
| 2017-12-30 10:34:00 | Mechanistically, the effect of montelukast on osteoblastic differentiation acted by activating the extracellular regulated protein kinases (ERK) pathway. The obtained results suggested that montelukast promotes proliferation and differentiation in osteoblasts exposed to overload mechanics. | 29032198 |
| Type | IDs |
|---|---|
| Synonymous | BB147369, CysLT1R, Cyslt1 |
| Gene |
UniProtKB-ID:
CLTR1_MOUSE
UniprotKB:
Q99JA4
UniParc:
UPI000002A6BC,
UPI0000001A33
EMBL:
AF329272,
BC027102,
AL732460,
AF263370,
AB044087,
AK033476,
AF205830
Ensembl:
ENSMUSG00000052821
KO:
mmu:58861
|
| Nucleutide sequences |
EMBL-CDS:
AAK16715.1,
BAC28308.1,
AAK16716.1,
AAF73047.1,
AAK15433.1,
AAH27102.1,
BAA96809.1
Ensembl_TRS:
ENSMUST00000113480,
ENSMUST00000064892
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000063520,
ENSMUSP00000109108
RefSeq:
NP_067451.2,
NP_001268788.1,
XP_036017948.1,
NP_001268791.1
|
| Others |
UniRef100:
UniRef100_Q99JA4
UniRef90:
UniRef90_Q99JA4
UniRef50:
UniRef50_Q99JA4
UniGene:
Mm.287166
CCDS:
CCDS41098.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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