| Type | Description |
|---|---|
| Definition | nuclear receptor subfamily 1, group H, member 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 12:40:00 | The present work's main objective was to study the effect of different high fat diets on LXRs expression (in hypothalamus and liver), and lipid profile. | 31161476 |
| 2019-06-08 10:54:00 | We observed increased expression of LXRalpha from an early stage of nephrosis. To explore the role of increased LXRalpha in diseased kidney in vitro, NRK52E, normal kidney tubular epithelial cells, were forced to overexpress LXRalpha. These cells showed significantly lower lipid accumulation than mock cells did. In contrast, LXRbeta knockdown led to increased lipid accumulation in mock cells, and constancy in overexpre... | 30471864 |
| 2019-02-23 12:40:00 | Results show that hippocampal LXRbeta levels were negatively correlated with the severity of the depressive-like behaviors. LXRbeta knockdown in hippocampus produced depression-like behaviors and impaired hippocampal neurogenesis, and conversely, the LXRbeta activation improved the depression-like behaviors and reversed the impaired hippocampal neurogenesis in rats. | 29654801 |
| 2017-11-25 14:42:00 | SHP promoted SUMO1 attachment to LXRbeta by stabilizing the E3 SUMO ligase PIAS1. | 27485016 |
| 2017-02-18 10:18:00 | Data show that TO901317 increased expression of both Liver X receptors (LXRalpha and LXRbeta) isoforms and its target genes: sterol response element binding protein 1c (SREBP-1c) and acetyl-coenzyme A carboxylase 1 (ACC1) in the heart of streptozotocin-diabetes. | 27352290 |
| Type | IDs |
|---|---|
| Synonymous | LXR beta, LXRB, LXRbeta, OR-1 |
| Gene |
UniProtKB-ID:
NR1H2_RAT
UniprotKB:
Q62755
UniParc:
UPI000013050B
EMBL:
U20389,
U14533
Ensembl:
ENSRNOG00000019812
KO:
rno:58851
|
| Nucleutide sequences |
EMBL-CDS:
AAA69522.1,
AAA52361.1
Ensembl_TRS:
ENSRNOT00000026862
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000026862
RefSeq:
NP_113814.2
|
| Others |
UniRef100:
UniRef100_Q62755
UniRef90:
UniRef90_Q62755
UniRef50:
UniRef50_Q60644
UniGene:
Rn.786
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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