RAD17 - RAD17 checkpoint clamp loader component-BMKCloudï½ç¾è¿å®¢äº

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5884 RAD17

基因描述

Type	Description
Definition	RAD17 checkpoint clamp loader component

研究结论

Date	Results	Publications
2021-03-28 19:06:00	IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.	32896617
2021-02-06 13:49:00	The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex.	31845510
2020-06-13 12:32:00	Human Rad17 is constitutively phosphorylated in vivo on a C-terminal threonine, T670. Rad17-T670 is phosphorylated by casein kinase 1delta/epsilon.	31353086
2019-04-06 10:08:00	The potential G-quadruplex sequence (PQS) of the RAD17 gene promoter was analyzed in different sequence contexts. With two extra nucleotides of the native sequence on either side of the G4, the structure was found to fold into a hybrid-like G4, similar to the hybrid-1 fold that the human telomere sequence can adopt.	30063821
2019-03-30 11:46:00	Rad17-S667 in the C-terminal tail is constitutively phosphorylated in vivo in a casein kinase 2-dependent manner, and the phosphorylation is important for 9-1-1 interaction	29902452

名称对应

Type	IDs
Synonymous	CCYC, HRAD17, R24L, RAD17SP, RAD24
Gene	UniProtKB-ID: RAD17_HUMAN UniprotKB: O75943 UniParc: UPI00000727FD, UPI000013DD06, UPI000007093C, UPI0000073E7D EMBL: AL122068, AJ001642, AJ131307, AJ131296, AF112263, AF017748, AJ004977, AF098534, AJ131308, AY612854, AF076838, BX537441, AJ131301, BC032304, AJ131303, AJ131304, AJ131302, AJ131306, AF085736, AJ131299, AF126424, AK292487, CH471137, AJ131300, AF098533, AJ131305, AJ131297, AJ131298 Ensembl: ENSG00000152942, ENSG00000276618 KO: hsa:5884
Nucleutide sequences	EMBL-CDS: EAW51286.1, CAA04894.1, CAA06251.1, AAC95520.1, AAC97951.1, EAW51288.1, CAB59244.1, AAD17334.1, BAF85176.1, CAB46364.1, EAW51285.1, CAD97683.1, EAW51284.1, AAC36334.1, AAD01620.1, AAC97950.1, AAT09763.1, EAW51283.1, AAH32304.1, AAD38878.1 Ensembl_TRS: ENST00000305138, ENST00000521422, ENST00000509734, ENST00000611523, ENST00000345306, ENST00000282891, ENST00000620889, ENST00000610770, ENST00000616488, ENST00000354312, ENST00000361732, ENST00000380774, ENST00000612044, ENST00000616759, ENST00000616683, ENST00000354868, ENST00000358030
Protein sequencees	Ensembl_PRO: ENSP00000479160, ENSP00000370151, ENSP00000346271, ENSP00000346938, ENSP00000311227, ENSP00000282891, ENSP00000477962, ENSP00000426191, ENSP00000477996, ENSP00000484854, ENSP00000427743, ENSP00000303134, ENSP00000482775, ENSP00000478167, ENSP00000350725, ENSP00000355226, ENSP00000482371 RefSeq: XP_016865170.1, NP_579916.1, NP_579918.1, NP_579920.1, NP_579922.1, NP_579919.1, NP_001265551.1, NP_002864.1, NP_579921.1, NP_579917.1
Others	UniRef100: UniRef100_O75943 UniRef90: UniRef90_O75943 UniRef50: UniRef50_O75943 UniGene: Hs.16184 CCDS: CCDS4005.1, CCDS4003.1, CCDS47226.1, CCDS4004.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32896617	IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer. Cancer Lett Yulan Zeng , Xiaohua Jie , Bian Wu , Gang Wu , Li Liu , Shuangbing Xu	2020-11-28	-
31845510	The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex. Mol Oncol Jiancheng Xu , Guangchao Wang , Wei Gong , Shichao Guo , Dan Li , Qimin Zhan	2020-03-01	-
31353086	Human Rad17â¯C-terminal tail is phosphorylated by concerted action of CK1Î´/Îµ and CK2 to promote interaction with the 9-1-1 complex. Biochem Biophys Res Commun Yasunori Fukumoto , Yuji Nakayama , Naoto Yamaguchi	2019-09-17	-
29902452	Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17. Biochem Biophys Res Commun Yasunori Fukumoto , Kazuaki Takahashi , Noriyuki Suzuki , Yasumitsu Ogra , Yuji Nakayama , Naoto Yamaguchi	2018-10-02	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
30063821	The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification. ACS Chem. Biol. Judy Zhu , Aaron M Fleming , Cynthia J Burrows	2018-09-21	-
30061412	Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. Proc. Natl. Acad. Sci. U.S.A. Takuya Abe , Masato Ooka , Ryotaro Kawasumi , Keiji Miyata , Minoru Takata , Kouji Hirota , Dana Branzei	2018-08-14	-
28666868	The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex. Biochem. Biophys. Res. Commun. Yasunori Fukumoto , Yuji Nakayama , Naoto Yamaguchi	2017-09-02	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
28238011	Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer. Acta Med. Okayama Yukiko Yasuda , Akiko Sakai , Sachio Ito , Kaori Sasai , Hiromasa Yamamoto , Nagahide Matsubara , Mamoru Ouchida , Hiroshi Katayama , Kenji Shimizu	2017-02-01	-

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