| Type | Description |
|---|---|
| Definition | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:32:00 | genetic ablation of AKR1A activates the PGC-1alpha pathway and spare glucose, which would consequently confer exercise endurance | 32142766 |
| 2018-07-21 10:34:00 | Data (including data from studies in knockout and transgenic mice) suggest that Akr1a1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. | 29763686 |
| 2018-03-03 10:55:00 | Akr1A1 gene knockout mice exhibit insufficient serum ascorbic acid levels, abnormal bone development and osteoporosis. | 28060768 |
| 2017-12-23 10:48:00 | These results suggest that Akr1a might be involved in the metabolism of steroids and other carbonyl-containing compounds. | 27888021 |
| 2017-05-20 14:30:00 | Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties. | 27501753 |
| Type | IDs |
|---|---|
| Synonymous | 2610201A18Rik, Akr1a4 |
| Gene |
UniProtKB-ID:
AK1A1_MOUSE,
Q80XJ7_MOUSE,
Q540D7_MOUSE
UniprotKB:
Q9JII6,
Q80XJ7,
Q540D7
UniParc:
UPI000000BABD,
UPI0000006C1D
EMBL:
AF225564,
AK011388,
AK011221,
AK011667,
AK011906,
AY207463,
AK164461,
BC039926,
AK152086,
AK011856,
BC046762,
AK011908,
AK011321,
AK011918,
AK146081,
AK009462,
AK168950,
AK144198,
AK011794,
AK011157,
AK005162,
AK011209
Ensembl:
ENSMUSG00000028692
KO:
mmu:58810
|
| Nucleutide sequences |
EMBL-CDS:
BAB27543.1,
BAB27846.1,
BAB27469.1,
BAB23853.1,
BAB27909.1,
BAB27586.1,
BAB27907.1,
AAH39926.1,
BAB26303.1,
BAB27883.1,
BAB27437.1,
BAB27915.1,
AAF67111.1,
BAB27767.1,
AAH46762.1,
BAE30936.1,
BAE26885.1,
BAE40756.1,
BAE25762.1,
AAO72145.1,
BAE37798.1
Ensembl_TRS:
ENSMUST00000030455
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030455
RefSeq:
NP_067448.1
|
| Others |
UniRef100:
UniRef100_Q9JII6,
UniRef100_Q80XJ7
UniRef90:
UniRef90_Q9JII6
UniRef50:
UniRef50_P14550
UniGene:
Mm.30085,
Mm.489607
CCDS:
CCDS18514.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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