| Type | Description |
|---|---|
| Definition | potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-30 11:04:00 | conclude that seizure-induced downregulation of KCNMB4 is an activity dependent mechanism that increases the excitability of DG neurons. These novel findings indicate that BK channel subtypes are not only defined by cell-specific expression, but can also be plastic depending on the recent history of neuronal excitability | 29145442 |
| 2017-09-09 11:49:00 | These results indicate that an important role of the beta4-subunit is to reduce ryanodine receptor-BK channel functional coupling during the afterhyperpolarization component of the action potential, thereby decreasing excitability of dentate gyrus neurons. | 27146987 |
| 2016-05-07 12:20:00 | the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption | 24573316 |
| 2012-03-31 11:50:00 | BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining potassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function. | 21438011 |
| 2010-01-21 00:00:00 | E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4 | 17962348 |
| Type | IDs |
|---|---|
| Synonymous | 1700058G18Rik, 2900045G12Rik |
| Gene |
UniProtKB-ID:
KCMB4_MOUSE
UniprotKB:
Q9JIN6
UniParc:
UPI00000285A0
EMBL:
AF215892,
BC117779
Ensembl:
ENSMUSG00000054934
KO:
mmu:58802
|
| Nucleutide sequences |
EMBL-CDS:
AAI17780.1,
AAF75597.1
Ensembl_TRS:
ENSMUST00000068233
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000065384
RefSeq:
NP_067427.1,
XP_036011795.1,
XP_006513974.1
|
| Others |
UniRef100:
UniRef100_Q9JIN6
UniRef90:
UniRef90_Q9JIN6
UniRef50:
UniRef50_Q9JIN6
UniGene:
Mm.440652
CCDS:
CCDS24184.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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