| Type | Description |
|---|---|
| Definition | Rac family small GTPase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:01:00 | The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. | 32636302 |
| 2020-10-24 13:57:00 | A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease. | 31382036 |
| 2020-05-23 12:05:00 | These results collectively suggest that Rac2 plays a critical, previously unrecognized, role in natural killer cell cytotoxicity | 31491520 |
| 2020-05-02 11:52:00 | patients with a monoallelic activating RAC2 mutation have increased actin polymerization, exaggerated neutrophilic oxidative burst, lymphopenia, and increased lymphocyte apoptosis. This combined immunodeficiency indicates the importance of regulating RAC2 activity for intact immune function. | 30654050 |
| 2020-04-18 12:28:00 | This study reveals an intricate balance between Rac2 and Wiskott-Aldrich syndrome protein (WASp) signaling pathways and provides an example of compensatory pathways in cells devoid of the Cdc42 effector WASp. | 28129089 |
| Type | IDs |
|---|---|
| Synonymous | EN-7, Gx, HSPC022, p21-Rac2 |
| Gene |
UniProtKB-ID:
RAC2_HUMAN,
V9H0H7_HUMAN,
A0A024R1P2_HUMAN
UniprotKB:
P15153,
V9H0H7,
A0A024R1P2
UniParc:
UPI0000070BF8,
UPI00001110AB
EMBL:
Z82188,
AF498965,
BT006919,
M64595,
M29871,
CR456555,
AF077208,
BC001485,
CH471095
Ensembl:
ENSG00000128340
KO:
hsa:5880
|
| Nucleutide sequences |
EMBL-CDS:
AAH01485.1,
AAA35941.1,
AAA36538.1,
CAG30441.1,
AAP35565.1,
AAM21112.1,
AAD27003.1,
EAW60153.1,
EAW60149.1
Gene_ORFName:
hCG_1811995
Ensembl_TRS:
ENST00000249071
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000249071
RefSeq:
NP_002863.1,
XP_006724349.1
|
| Others |
UniRef100:
UniRef100_V9H0H7,
UniRef100_P15153
UniRef90:
UniRef90_P15153,
UniRef90_A0A2I2ZYV1
UniRef50:
UniRef50_A0A2I2ZYV1,
UniRef50_P15153
UniGene:
Hs.517601
CCDS:
CCDS13945.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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