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585 BBS4

585

BBS4

Bardet-Biedl syndrome 4

protein-coding

Homo sapiens

基因描述

Type Description
Definition Bardet-Biedl syndrome 4

研究结论

Date Results Publications
2021-02-27 13:45:00 The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells. 32759308
2015-10-03 10:24:00 a novel nonsense mutation in BBS4 gene in a Chinese family with Bardet-Biedl syndrome. This homozygous mutation was predicted to completely abolish the synthesis of the BBS4 protein; a rare heterozygous missense SNP in BBS10 gene was also detected 25533820
2015-08-15 10:06:00 Results present evidence of a role for BBS4 in mediating the phosphorylation of TrkB by BDNF and its activation requires a proper localization to the ciliary axoneme. 24867303
2015-05-16 11:40:00 mediates endosomal recycling, sorting and signal transduction of Notch receptors 24681783
2014-06-21 13:07:00 loss of BBS1, BBS4, or OFD1 led to decreased NF-kappaB activity and concomitant IkappaBbeta accumulation and that these defects were ameliorated with SFN treatment. 24691443

名称对应

Type IDs
Gene
UniProtKB-ID: BBS4_HUMAN, A0A0S2Z3A9_HUMAN
UniprotKB: Q96RK4, A0A0S2Z3A9
UniParc: UPI00017A882D, UPI000013D78E, UPI000050B615
EMBL: CH471082, AK075321, AY457143, AF359281, AC009712, AK303706, BC008923, KU177936, BC027624
Ensembl: ENSG00000140463
KO: hsa:585
Nucleutide sequences
EMBL-CDS: AAK58868.1, AAH08923.2, AAH27624.1, BAC11547.1, BAG64690.1, AAS13441.1, ALQ33394.1, EAW77912.1
Gene_ORFName: hCG_40463
Ensembl_TRS: ENST00000268057, ENST00000395205
Protein sequencees
Ensembl_PRO: ENSP00000378631, ENSP00000268057
RefSeq: XP_016877939.1, XP_016877943.1, NP_001307594.1, NP_001239607.1, XP_011520150.1, NP_149017.2, XP_011520151.1, XP_016877941.1, XP_016877942.1, XP_011520153.1
Others
UniRef100: UniRef100_Q96RK4
UniRef90: UniRef90_Q96RK4
UniRef50: UniRef50_Q96RK4
UniGene: Hs.208681
CCDS: CCDS10246.1, CCDS58377.1

全选

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