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58494 JAM2

58494

JAM2

junctional adhesion molecule 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition junctional adhesion molecule 2

研究结论

Date Results Publications
2020-07-11 10:07:00 mutant JAM2 protein resulted in impaired cell-cell adhesion functions and reduced integrity of the neurovascular unit 31851307
2020-05-09 12:33:00 Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the movement of solutes through the paracellular spaces in the neurovascular unit is a key mechanism in CNS calcification 32142645
2019-10-05 11:04:00 iR-374b significantly inhibits cell proliferation, migration, and invasion through the blockade of the p38/ERK signaling pathway activation, as well as negatively binding to JAM-2 29575013
2017-03-18 12:33:00 this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review] 27121546
2016-12-17 12:05:00 JAM-2 may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer 26782073

名称对应

Type IDs
Synonymous C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM
Gene
UniProtKB-ID: JAM2_HUMAN
UniprotKB: P57087
UniParc: UPI000012DAA4, UPI00017A6E6A, UPI0000035970
EMBL: AP000224, AK294769, AK312708, AY077698, AY016009, AP000226, AF255910, AY358361, AP000225, AP000223, BC017779
Ensembl: ENSG00000154721
KO: hsa:58494
Nucleutide sequences
EMBL-CDS: BAG57900.1, BAG35586.1, AAL82538.1, AAH17779.1, AAF81223.1, AAG49022.1, AAQ88727.1
Gene_ORFName: UNQ219/PRO245
Ensembl_TRS: ENST00000400532, ENST00000312957, ENST00000480456
Protein sequencees
Ensembl_PRO: ENSP00000318416, ENSP00000383376, ENSP00000420419
RefSeq: NP_001257337.1, NP_067042.1, XP_024307891.1, XP_024307892.1, NP_001257336.1
Others
UniRef100: UniRef100_P57087
UniRef90: UniRef90_P57087
UniRef50: UniRef50_P57087
UniGene: Hs.517227
CCDS: CCDS58788.1, CCDS58787.1, CCDS42911.1

全选

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