| Type | Description |
|---|---|
| Definition | tumor protein p53 inducible nuclear protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 12:26:00 | TP53INP2 interacted directly with ATG7 to form a LC3B-TP53INP2-ATG7 complex in the cytoplasm. | 30767704 |
| 2020-06-06 13:21:00 | Results showed that TP53INP2 interacts with ubiquitin and ubiquitinated proteins through the ubiquitin-interacting motif (UIM). Moreover, overexpression of TP53INP2 lacking the UIM in cells leads to massive accumulation of ubiquitinated proteins and sensitizes the cells to apoptosis under stressed conditions. | 31155706 |
| 2020-01-11 10:45:00 | A screen of cancer cell lines showed that those with higher protein levels of TP53INP2 are more prone to TRAIL-induced apoptosis, making TP53INP2 a potential predictive marker of cancer cell responsiveness to TRAIL treatment. These findings uncover a novel mechanism for the regulation of caspase-8 ubiquitination and reveal TP53INP2 as an important regulator of the death receptor pathway. | 30979779 |
| 2019-11-16 12:58:00 | Tp53inp2 is an atypical mRNA that regulates axon growth by enhancing NGF-TrkA signaling in a translation-independent manner. | 30853298 |
| 2019-04-20 11:11:00 | TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity. | 29593329 |
| Type | IDs |
|---|---|
| Synonymous | C20orf110, DOR, PIG-U, PIGU, PINH, dJ1181N3.1 |
| Gene |
UniProtKB-ID:
T53I2_HUMAN
UniprotKB:
Q8IXH6
UniParc:
UPI0000074230
EMBL:
AY422170,
CH471077,
AK292443,
AL109824,
BC035639,
AJ297792
Ensembl:
ENSG00000078804
KO:
hsa:58476
|
| Nucleutide sequences |
EMBL-CDS:
AAH35639.1,
AAR23799.1,
EAW76257.1,
BAF85132.1,
EAW76256.1,
CAC82592.1
Ensembl_TRS:
ENST00000374809,
ENST00000374810
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363942,
ENSP00000363943
RefSeq:
NP_067025.1,
XP_006723904.1,
NP_001316360.1,
NP_001316359.1,
NP_001316358.1
|
| Others |
UniRef100:
UniRef100_Q8IXH6
UniRef90:
UniRef90_Q8IXH6
UniRef50:
UniRef50_Q8IXH6
UniGene:
Hs.516994
CCDS:
CCDS13240.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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