| Type | Description |
|---|---|
| Definition | pyrroline-5-carboxylate reductase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:42:00 | Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis. | 31987921 |
| 2020-08-15 19:07:00 | PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer. | 31619254 |
| 2020-07-25 12:10:00 | Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) K1 oncoprotein interacted with and activated PYCR enzyme, increasing intracellular proline concentration. Consequently, the K1-PYCR interaction promoted tumor cell growth in 3D spheroid culture and tumorigenesis in nude mice. This study demonstrates that an increase of proline biosynthesis induced by K1-PYCR interaction is critical for KSHV-mediated tumorigenesis. | 32213586 |
| 2020-07-25 11:47:00 | PYCR1 plays a role in the proliferation, epithelial-mesenchymal transition and drug resistance by regulating p38 MAPK and NF-kappaB signalling pathways in the colorectal cancer cells.PYCR1 is highly espressed in tissues and cells of the colorectal cancer patients. | 31606203 |
| 2020-07-11 11:49:00 | High PYCR1 expression is associated with lung adenocarcinoma. | 32133692 |
| Type | IDs |
|---|---|
| Synonymous | ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR |
| Gene |
UniProtKB-ID:
P5CR1_HUMAN,
Q8TBX0_HUMAN,
E2QRB3_HUMAN,
J3QL32_HUMAN,
A0A024R8U9_HUMAN
UniprotKB:
P32322,
Q8TBX0,
E2QRB3,
J3QL32,
A0A024R8U9
UniParc:
UPI0000163C1F,
UPI0000161188,
UPI0000D4DCB3,
UPI00000729CD,
UPI00017A78A7,
UPI0000D4C30E
EMBL:
BC022244,
AC145207,
AK297627,
BC001504,
CR541769,
CH471099,
M77836,
AF218000,
BC071842
Ensembl:
ENSG00000183010
KO:
hsa:5831
|
| Nucleutide sequences |
EMBL-CDS:
BAG60002.1,
AAH71842.1,
AAH01504.1,
AAG17242.1,
CAG46568.1,
EAW89724.1,
AAA36407.1,
AAH22244.1,
EAW89719.1,
EAW89717.1,
EAW89720.1,
EAW89723.1,
EAW89721.1,
EAW89725.1
Gene_ORFName:
hCG_38803,
hCG_38803,
hCG_38803
Ensembl_TRS:
ENST00000329875,
ENST00000402252,
ENST00000619204,
ENST00000337943,
ENST00000403172,
ENST00000577756,
ENST00000629768
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384949,
ENSP00000336579,
ENSP00000479793,
ENSP00000328858,
ENSP00000385483,
ENSP00000463352,
ENSP00000485679
RefSeq:
XP_024306617.1,
NP_001317452.1,
XP_011521886.1,
XP_011521885.1,
NP_008838.2,
NP_001269208.1,
XP_005256438.1,
NP_001269209.1,
NP_001269210.1,
XP_011521887.1,
NP_722546.1
|
| Others |
UniRef100:
UniRef100_J3QL32,
UniRef100_P32322,
UniRef100_E2QRB3
UniRef90:
UniRef90_P32322,
UniRef90_J3QL32
UniRef50:
UniRef50_P32322,
UniRef50_A0A452UJC3
UniGene:
Hs.163451
CCDS:
CCDS62366.1,
CCDS11795.1,
CCDS11794.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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