| Type | Description |
|---|---|
| Definition | ring finger protein 8 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:33:00 | RNF8 induces autophagy and reduces inflammation by promoting AKT degradation via ubiquitination in ulcerative colitis mice. | 32597970 |
| 2019-09-14 11:50:00 | deficiency of RNF8 sensitized breast cancer cells to combination of pharmacological inhibitors of Notch signaling and poly(ADP-ribose) polymerase suggesting implications for treatment of breast cancer associated with impaired RNF8 expression or function. | 30222135 |
| 2019-08-31 12:23:00 | Results reveal that RAD6B and RNF8 contribute to nucleosome removal during spermiogenesis. | 28825854 |
| 2018-10-06 10:15:00 | Knockdown or conditional knockout of RNF8 or UBC13 in rodent cerebellar granule neurons robustly increases the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. In contrast to the role of nuclear RNF8 in proliferating cells, RNF8 operates in the cytoplasm in neurons to suppress synapse differentiation. | 29097665 |
| 2018-07-21 10:40:00 | RNF8-dependent polyubiquitination is required for the establishment of H3K27 acetylation, a marker of active enhancers, while persistent H2AK119ub inhibits establishment of H3K27 acetylation. Following the deposition of H3K27 acetylation, H3K4 dimethylation is established as an active mark on poised promoters. | 29462142 |
| Type | IDs |
|---|---|
| Synonymous | 3830404E21Rik, AIP37, laXp180 |
| Gene |
UniProtKB-ID:
RNF8_MOUSE
UniprotKB:
Q8VC56
UniParc:
UPI0000004103
EMBL:
AK147168,
CT010295,
AJ242721,
AK076180,
BC021778
Ensembl:
ENSMUSG00000090083
KO:
mmu:58230
|
| Nucleutide sequences |
EMBL-CDS:
BAE27732.1,
AAH21778.1,
CAJ18503.1,
CAB92239.1,
BAC36236.1
Ensembl_TRS:
ENSMUST00000024817
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024817
RefSeq:
NP_067394.1
|
| Others |
UniRef100:
UniRef100_Q8VC56
UniRef90:
UniRef90_Q8VC56
UniRef50:
UniRef50_O76064
UniGene:
Mm.305994
CCDS:
CCDS37538.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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