| Type | Description |
|---|---|
| Definition | SH3-domain kinase binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 11:57:00 | Data show that Cbl-interacting protein of 85 kDa (CIN85) limited T cell responses to T cell receptor (TCR) stimulation. | 30723173 |
| 2018-06-30 11:17:00 | Cin85-deficient mother mice had reduced pituitary hormone prolactin secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited. | 29158391 |
| 2018-05-12 11:03:00 | competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process. | 29589748 |
| 2017-06-03 10:23:00 | CIN85/RukL is involved in endocytosis of nephrin in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes. | 27531950 |
| 2014-01-11 10:04:00 | Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons. | 23506116 |
| Type | IDs |
|---|---|
| Synonymous | 1200007H22Rik, 1700125L08Rik, 5830464D22Rik, AI447724, Cin85, IN85, Ruk, Seta |
| Gene |
UniProtKB-ID:
SH3K1_MOUSE,
Q3TA88_MOUSE,
Q3TT90_MOUSE
UniprotKB:
Q8R550,
Q3TA88,
Q3TT90
UniParc:
UPI00000E7141,
UPI00000286A7,
UPI00000E8886,
UPI000019C40E,
UPI00000286AC,
UPI00000E72DB,
UPI00000286AF,
UPI00000286C7
EMBL:
AF472307,
AF472319,
AK020782,
AL929452,
AF472316,
AI428677,
AK004636,
AF472325,
AF472322,
AF472306,
AF472324,
AK038540,
AF472315,
AF472327,
AF472310,
AF472317,
AF472314,
AF472318,
AF472309,
AK161512,
AF472320,
AF472305,
AF472308,
AF472312,
AF472311,
AK172022,
AF243508,
AF472313,
AF472326,
AK049182,
AF472304,
AK142295,
AF472323,
AF472321
Ensembl:
ENSMUSG00000040990
KO:
mmu:58194
|
| Nucleutide sequences |
EMBL-CDS:
BAC30033.1,
BAB32209.2,
AAL82459.1,
AAL82458.1,
AAL82461.1,
AAL82457.1,
BAC33592.1,
AAL82460.1,
BAB23427.2,
AAL82462.1,
AAF68439.1,
AAL82456.1,
BAE42781.1,
BAE36435.1,
BAE25017.1
Ensembl_TRS:
ENSMUST00000080394,
ENSMUST00000073094,
ENSMUST00000112453,
ENSMUST00000112456,
ENSMUST00000112451
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108070,
ENSMUSP00000108072,
ENSMUSP00000072840,
ENSMUSP00000108075,
ENSMUSP00000079257
RefSeq:
XP_030107292.1,
XP_011246153.1,
XP_030107290.1,
NP_067364.2,
XP_017174075.1,
XP_006528988.1,
XP_006528992.1,
XP_006528990.1,
XP_036017947.1,
XP_030107293.1,
NP_001129200.1,
NP_001129199.1,
NP_001277590.1,
XP_017174073.1,
XP_030107291.1,
XP_006528995.1,
NP_001277593.1,
XP_006528987.1,
XP_006528991.1,
XP_036017946.1,
NP_001361630.1
|
| Others |
UniRef100:
UniRef100_Q8R550,
UniRef100_Q3TA88
UniRef90:
UniRef90_Q925Q9,
UniRef90_Q96B97
UniRef50:
UniRef50_Q96B97
UniGene:
Mm.286495
CCDS:
CCDS53235.1,
CCDS53234.1,
CCDS41194.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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