| Type | Description |
|---|---|
| Definition | SMAD family member 3a |
| Date | Results | Publications |
|---|---|---|
| 2017-09-16 11:08:00 | Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1; Smad3a = SMAD family member 3a) | 28687631 |
| 2015-02-07 11:47:00 | Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta control of zebrafish spinal cord development | 25286120 |
| 2010-01-21 00:00:00 | although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine-tuning of this signal transduction cascade | 18039968 |
| 2010-01-21 00:00:00 | Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning. | 18025082 |
| 2010-01-21 00:00:00 | Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis | 19580801 |
| Type | IDs |
|---|---|
| Synonymous | madh3, madh3a, smad3, wu:fa99e03 |
| Gene |
UniProtKB-ID:
Q8AY15_DANRE
UniprotKB:
Q8AY15
UniParc:
UPI00000FE1F7
EMBL:
CR927368,
AY134492,
BC129150,
CR352307
Ensembl:
ENSDARG00000117146,
ENSDARG00000036096
KO:
dre:58092
|
| Nucleutide sequences |
EMBL-CDS:
AAN08606.1,
AAI29151.1
Ensembl_TRS:
ENSDART00000045374,
ENSDART00000186800
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000152734,
ENSDARP00000045373
RefSeq:
NP_571646.1
|
| Others |
UniRef100:
UniRef100_Q8AY15
UniRef90:
UniRef90_P84023
UniRef50:
UniRef50_P84022-2
UniGene:
Dr.87309
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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