| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase receptor type K |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 10:18:00 | The authors report here that the homophilic receptor PTPRK is stabilized at cell-cell contacts in epithelial cells. PTPRK directly and selectively dephosphorylates at least five substrates, including Afadin, PARD3 and delta-catenin family members, which are all important cell-cell adhesion regulators. | 30924770 |
| 2019-11-16 12:10:00 | Knockdown of PTPRK potentiates the pro-oncogenic CD133-AKT pathway in colon cancer cells. | 30947381 |
| 2019-08-31 11:52:00 | These results suggested that PTPRK functions as a novel tumor suppressor in NSCLC, and its suppressive ability may be involved in activation. | 30838170 |
| 2019-08-17 10:53:00 | the lower PTPRK expression was observed in Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1) positive cancer stem cells (CSCs) population, suggesting the role of PTPRK downregulation in primary as well as acquired resistance to cytotoxic drugs. | 31027318 |
| 2019-01-19 10:48:00 | Study show that RAS at the Golgi is selectively activated by apoptogenic stimuli and antagonizes cell survival by suppressing ERK activity through the induction of PTPRkappa, which targets CRAF for dephosphorylation. RAS oncogenic potential is strictly dependent on its sublocalization, with Golgi complex-located RAS antagonizing tumor development. | 30185827 |
| Type | IDs |
|---|---|
| Synonymous | R-PTP-kappa |
| Gene |
UniProtKB-ID:
PTPRK_HUMAN,
B4DHC3_HUMAN,
Q86WJ2_HUMAN,
Q5TG12_HUMAN,
Q59EZ1_HUMAN
UniprotKB:
Q15262,
B4DHC3,
Q86WJ2,
Q5TG12,
Q59EZ1
UniParc:
UPI0001747A04,
UPI0000148ED1,
UPI000189A90C,
UPI00017A6E4C,
UPI000013DCFE,
UPI0000470982,
UPI000000D7E7,
UPI00004F6DB8
EMBL:
AL035594,
AF533875,
BC140775,
BC144512,
AC212491,
KF458278,
AK295028,
KF458282,
AL357621,
AL451073,
BC144513,
AB209670,
AL034349,
AL590006,
CH471051,
AL035465,
Z70660,
L77886,
AL035470
Ensembl:
ENSG00000273993,
ENSG00000152894
KO:
hsa:5796
|
| Nucleutide sequences |
EMBL-CDS:
AAC37599.1,
AAI40776.1,
AAI44514.1,
EAW48086.1,
CAA94519.1,
AAI44513.1,
BAG58084.1,
AAO49502.1,
BAD92907.1
Ensembl_TRS:
ENST00000532331,
ENST00000368226,
ENST00000628183,
ENST00000618924,
ENST00000619256,
ENST00000368213,
ENST00000618215,
ENST00000368215,
ENST00000625760,
ENST00000368210
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000477791,
ENSP00000357209,
ENSP00000483766,
ENSP00000432973,
ENSP00000486442,
ENSP00000484742,
ENSP00000357196,
ENSP00000357198,
ENSP00000487066,
ENSP00000357193
RefSeq:
XP_011534316.1,
XP_011534318.1,
NP_002835.2,
XP_011534317.1,
XP_016866637.1,
XP_011534319.1,
XP_006715600.1,
XP_016866634.1,
XP_016866638.1,
XP_011534322.1,
NP_001278913.1,
XP_011534323.1,
XP_016866639.1,
XP_011534320.1,
NP_001129120.1,
XP_016866636.1,
NP_001278911.1,
XP_016866635.1,
NP_001278910.1,
NP_001278912.1
|
| Others |
UniRef100:
UniRef100_Q15262,
UniRef100_Q86WJ2,
UniRef100_Q59EZ1,
UniRef100_Q5TG12,
UniRef100_B4DHC3
UniRef90:
UniRef90_Q15262,
UniRef90_A0A1S3WDR0,
UniRef90_A0A452EB94
UniRef50:
UniRef50_A0A1A8GID1,
UniRef50_A0A0S7FJ68,
UniRef50_Q15262
UniGene:
Hs.155919
CCDS:
CCDS5137.1,
CCDS75517.1,
CCDS47473.1,
CCDS78179.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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