| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase non-receptor type 12 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:58:00 | tumor suppressing gene [review] | 32541467 |
| 2020-03-28 10:26:00 | This review provides an overview of PTPN12 and discusses the critical roles of PTPN12 in tumor progression. [review] | 30959160 |
| 2020-02-29 11:04:00 | This study identifies PTPN12 expression measurement as a valuable prognostic marker in prostate cancer. | 31606028 |
| 2020-02-15 10:41:00 | PTPN12 rs3750050 could impair the inhibitory effect of PTPN12 on Ras/MEK/ERK signaling by impeding SHC dephosphorylation, increase the expression of cyclin D1 and ultimately lead to aberrant cell proliferation, thus contributing to colorectal cancer pathogenesis. | 30731403 |
| 2019-10-05 10:07:00 | These results show that oxidation of PTPN12 accounts for ABL1 phosphorylation in HLRCC-associated PRCC, revealing a novel mechanism for inactivating a tumor suppressor gene product and establishing a direct link between pathologic PTP oxidation and neoplastic disease. | 30297534 |
| Type | IDs |
|---|---|
| Synonymous | PTP-PEST, PTPG1 |
| Gene |
UniProtKB-ID:
PTN12_HUMAN,
B4E105_HUMAN
UniprotKB:
Q05209,
B4E105
UniParc:
UPI00017BE9AC,
UPI00017A844C,
UPI000013CC4C,
UPI000020F462
EMBL:
AB209524,
AK289573,
AK303602,
BC050008,
D13380,
CH471091,
AK296764,
AC006451,
M93425,
CH236949,
S69184
Ensembl:
ENSG00000127947
KO:
hsa:5782
|
| Nucleutide sequences |
EMBL-CDS:
EAW77036.1,
BAD92761.1,
AAA36529.1,
BAA02648.1,
AAH50008.2,
EAL24198.1,
BAF82262.1,
AAQ96881.1,
AAB30047.2,
EAW77037.1,
BAG59344.1,
BAG64617.1
Ensembl_TRS:
ENST00000415482,
ENST00000248594,
ENST00000435495
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000397991,
ENSP00000392429,
ENSP00000248594
RefSeq:
XP_006716136.1,
XP_005250575.1,
NP_002826.3,
NP_001124481.1,
XP_016867963.1,
NP_001124480.1
|
| Others |
UniRef100:
UniRef100_B4E105,
UniRef100_Q05209
UniRef90:
UniRef90_G1M2F9,
UniRef90_Q05209
UniRef50:
UniRef50_H0XVP9,
UniRef50_Q05209
UniGene:
Hs.61812
CCDS:
CCDS5592.1,
CCDS47619.1,
CCDS47620.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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