| Type | Description |
|---|---|
| Definition | CD200 receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:06:00 | Agonists of CD200R1 may be beneficial for eosinophilic pathologies. | 31365119 |
| 2020-03-21 11:39:00 | The results provided evidence that the expression changes of CD200-CD200R1 axis were highly correlated with neovascularization in retina. Activation of this axis showed strong anti-inflammatory and anti-angiogenic effects in an oxygen-induced retinopathy model, which revealed a new potential therapeutic target for retinal neovascularization treatment. | 31444514 |
| 2019-10-26 10:57:00 | blockade of the endogenous ligand CD200 prevented the tumorigenic effect of CD200R-expressing myeloid cells in the tumor microenvironment, whereas agonistic anti-CD200R has no effect on tumor development | 30653571 |
| 2019-06-15 12:28:00 | Study in CD200R-/- mice revealed that CD200R deficiency leads to enhanced bacterial burden in neutrophils. CD200R-deficient neutrophils display significantly reduced reactive oxygen species production suggesting that CD200R-mediated production in neutrophils is necessary for limiting F.tularensis colonization and proliferation. Overall, data show that CD200R promotes the antimicrobial properties of neutrophils. | 31073183 |
| 2019-06-01 10:34:00 | This study demonstrated that loss of CD200R1 led to high mortality, increased rates of post-stroke infection, and enhanced entry of peripheral leukocytes into the brain after ischemia, with no increase in infarct size. | 30777093 |
| Type | IDs |
|---|---|
| Synonymous | CD200R, Mox2r, OX2R |
| Gene |
UniProtKB-ID:
MO2R1_MOUSE
UniprotKB:
Q9ES57
UniParc:
UPI0000027744
EMBL:
BC052682,
AF231393
Ensembl:
ENSMUSG00000022667
KO:
mmu:57781
|
| Nucleutide sequences |
EMBL-CDS:
AAF98556.1,
AAH52682.1
Ensembl_TRS:
ENSMUST00000057488
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000053822
RefSeq:
NP_067300.1
|
| Others |
UniRef100:
UniRef100_Q9ES57
UniRef90:
UniRef90_Q9ES57
UniRef50:
UniRef50_Q9ES58
UniGene:
Mm.416152
CCDS:
CCDS28189.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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