| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase non-receptor type 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 12:13:00 | Study identified a nonsense mutation of PTPN4 with mutation ratio of 90.90% from 1 case of rectal cancer. Overexpression of PTPN4 suppressed the growth of colorectal cancer cells. PTPN4 dephosphorylates at the Tyr705 residue with a direct interaction and depresses the transcriptional activity of | 31025789 |
| 2019-03-16 13:08:00 | Data show that mutations affect the regulation of the protein tyrosine phosphatase non-receptor type 4 (PTPN4) bidomain and indicate that the PDZ-PDZ ligand regulation of PTPN4 is a linker-mediated mechanism. | 28801650 |
| 2017-11-11 12:05:00 | Binding assays confirmed that three (Cyto8-mtxd-1, Cyto8-mtxk-4 and Cyto8-mtxd-1k-4) out of the five designed peptides exhibit moderately or considerably increased affinity as compared to the native peptide Cyto8-RETEV | 27923202 |
| 2017-05-07 01:35:00 | the p38gamma.PTPN4 interaction promotes cellular signaling, preventing cell death induction. | 27246854 |
| 2016-05-28 12:33:00 | Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype. | 25424712 |
| Type | IDs |
|---|---|
| Synonymous | MEG, PTPMEG, PTPMEG1 |
| Gene |
UniProtKB-ID:
PTN4_HUMAN
UniprotKB:
P29074
UniParc:
UPI0000000CA9
EMBL:
BC010674,
AK314836,
M68941
Ensembl:
ENSG00000088179
KO:
hsa:5775
|
| Nucleutide sequences |
EMBL-CDS:
BAG37355.1,
AAH10674.1,
AAA36530.1
Ensembl_TRS:
ENST00000263708
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263708
RefSeq:
NP_002821.1
|
| Others |
UniRef100:
UniRef100_P29074
UniRef90:
UniRef90_P29074
UniRef50:
UniRef50_P29074
UniGene:
Hs.469809
CCDS:
CCDS2129.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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