| Type | Description |
|---|---|
| Definition | piwi-like RNA-mediated gene silencing 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 10:54:00 | we show that mitochondria-anchored TDRKH controls multiple steps of pachytene piRNA biogenesis in mice. TDRKH specifically recruits MIWI, but not MILI, to engage the piRNA pathway. It is required for the production of the entire MIWI-bound piRNA population and enables trimming of MILI-bound piRNAs. | 30590800 |
| 2017-09-23 11:38:00 | When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all PIWI-interacting RNA disappeared. | 28115634 |
| 2016-06-28 10:42:00 | MILI is responsible for DNA methylation of a larger subset of TE families than MIWI2. | 26279574 |
| 2016-05-28 10:44:00 | piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm. | 26669262 |
| 2015-04-18 10:56:00 | Knockdown of MILI in B16 cell line could activate MAGEA expression and increase the cell migration ability, whereas the overexpression of MILI in B16BL6 cell line could inhibit MAGEA expression and decrease the cell migration ability. | 25582775 |
| Type | IDs |
|---|---|
| Synonymous | Piwil1l, mili |
| Gene |
UniProtKB-ID:
PIWL2_MOUSE
UniprotKB:
Q8CDG1
UniParc:
UPI0000028F71
EMBL:
CH466535,
AK163647,
BC138444,
AB032605,
BC145717,
AK030116,
AF285586
Ensembl:
ENSMUSG00000033644
KO:
mmu:57746
|
| Nucleutide sequences |
EMBL-CDS:
AAI45718.1,
EDL35904.1,
AAK31965.1,
BAE37436.1,
AAI38445.1,
BAC26791.1,
BAA93706.1
Ensembl_TRS:
ENSMUST00000048129
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047385
RefSeq:
NP_067283.1,
NP_001351250.1,
XP_006519392.1
|
| Others |
UniRef100:
UniRef100_Q8CDG1
UniRef90:
UniRef90_Q8CDG1
UniRef50:
UniRef50_Q8CDG1
UniGene:
Mm.85253
CCDS:
CCDS27252.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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