EPG5 - ectopic P-granules autophagy protein 5 homolog-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

收藏

57724 EPG5

基因描述

Type	Description
Definition	ectopic P-granules autophagy protein 5 homolog

研究结论

Date	Results	Publications
2021-02-06 13:48:00	EPG5 c.1007A > G mutation in a sibling pair with rapidly progressing Vici syndrome.	31184778
2020-08-22 15:25:00	C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer.	31410206
2019-11-02 11:45:00	we successfully identified novel compound heterozygous mutations in EPG5 in a patient who was clinically considered to have Vici syndrome.	30152144
2019-05-18 12:06:00	To investigate the function of EPG5, siRNA based EPG5 knock-down, and CRISPR/Cas9 mediated EPG5 knock-out HeLa cells were generated. EPG5-depleted cells exhibited a complete block of autophagic flux caused by defective autophagosome-lysosome fusion.	28615637
2019-03-02 12:03:00	these findings indicate that EPG5, by controlling nucleic acids intracellular trafficking, links macroautophagy/autophagy to innate and adaptive immunity.	29130391

名称对应

Type	IDs
Synonymous	HEEW1, KIAA1632, VICIS
Gene	UniProtKB-ID: EPG5_HUMAN, Q9BTI0_HUMAN UniprotKB: Q9HCE0, Q9BTI0 UniParc: UPI000006DEBF, UPI00015C73E2, UPI00004F6F8A EMBL: AB046852, BC130614, AK023817, AC090355, BC003695, AC087685 Ensembl: ENSG00000152223 KO: hsa:57724
Nucleutide sequences	EMBL-CDS: BAB14689.1, AAI30615.1, BAB13458.1, AAH03695.1 Ensembl_TRS: ENST00000282041
Protein sequencees	Ensembl_PRO: ENSP00000282041 RefSeq: XP_016881381.1, XP_016881378.1, XP_016881379.1, NP_066015.2, XP_011524424.1, XP_016881380.1, XP_016881382.1
Others	UniRef100: UniRef100_Q9BTI0, UniRef100_Q9HCE0 UniRef90: UniRef90_Q9HCE0, UniRef90_A0A2K5JRP8 UniRef50: UniRef50_Q9HCE0 UniGene: Hs.514843 CCDS: CCDS11926.2

全选

{{proteinIndex+1}}

mRNA

Protein

UniprotKB

Description

Refseq

{{protein.nucleotideVersion}}

Ensembl: {{protein.nucleotideEnsembl}}

{{protein.proteinVersion}}

Ensembl: {{protein.proteinEnsembl}}

{{uniprot}}

Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

( {{protein.positionStart}}..{{protein.positionEnd}} )

暂无数据

收藏到我的文献

全选

Pubmed编号	文献信息	发表日期	相关基因
31184778	EPG5 c.1007AÂ >Â G mutation in a sibling pair with rapidly progressing Vici syndrome. Ann Hum Genet Eszter Vojcek , TÃ¡lia Magdolna Keszthelyi , Eszter JÃ¡vorszky , LÃdia Balogh , KÃ¡lmÃ¡n Tory	2020-01-01	-
30931944	USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nat Commun Haifeng Gu , Xingxing Shi , Chao Liu , Chaoqun Wang , Ning Sui , Yu Zhao , Jiaqi Gong , Fuping Wang , Hong Zhang , Wei Li , Tongbiao Zhao	2019-04-01	-
30575818	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene Katrin Tiemann , Carolina Garri , Sang Bok Lee , Paymaneh D Malihi , Mincheol Park , Ruth M Alvarez , Li Peng Yap , Parag Mallick , Jonathan E Katz , Mitchell E Gross , Kian Kani	2019-04-01	-
31410206	C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer. Theranostics Hui Li , Juan Liu , Wenjie Cao , Xiaojuan Xiao , Long Liang , Feng Liu-Smith , Weiwei Wang , Hong Liu , Peng Zhou , Ruoyun Ouyang , Zhijun Yuan , Jing Liu , Mao Ye , Bin Zhang	2019-01-01	-
30152144	Novel compound heterozygous EPG5 mutations consisted with a missense mutation and a microduplication in the exon 1 region identified in a Japanese patient with Vici syndrome. Am J Med Genet A Shino Shimada , Kyoko Hirasawa , Akiko Takeshita , Hidetsugu Nakatsukasa , Keiko Yamamoto-Shimojima , Taichi Imaizumi , Satoru Nagata , Toshiyuki Yamamoto	2018-12-01	-
29227033	Autopsy findings in EPG5-related Vici syndrome with antenatal onset: Additional report of Focal cortical microdysgenesis in a second trimester fetus. Am J Med Genet A Shagun Aggarwal , Ashwani Tandon , Aneek Das Bhowmik , Ashwin Dalal	2018-02-01	-
29130391	The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity. Autophagy E Piano Mortari , V Folgiero , V Marcellini , P Romania , E Bellacchio , V D'Alicandro , C Bocci , R Carrozzo , D Martinelli , S Petrini , E Axiotis , C Farroni , F Locatelli , U Schara , D T Pilz , H Jungbluth , C Dionisi-Vici , R Carsetti	2018-01-01	-
29507755	VIRMA mediates preferential m⁶A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov Yanan Yue , Jun Liu , Xiaolong Cui , Jie Cao , Guanzheng Luo , Zezhou Zhang , Tao Cheng , Minsong Gao , Xiao Shu , Honghui Ma , Fengqin Wang , Xinxia Wang , Bin Shen , Yizhen Wang , Xinhua Feng , Chuan He , Jianzhao Liu	2018-01-01	-
28986522	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Nat Commun Giulia Antoniali , Fabrizio Serra , Lisa Lirussi , Mikiei Tanaka , Chiara D'Ambrosio , Shiheng Zhang , Slobodanka Radovic , Emiliano Dalla , Yari Ciani , Andrea Scaloni , Mengxia Li , Silvano Piazza , Gianluca Tell	2017-10-06	-
28748650	Autopsy findings in EPG5-related Vici syndrome with antenatal onset. Renaud Touraine , Annie LaquerriÃ¨re , Carmen-Adina Petcu , Florent Marguet , Susan Byrne , Rachael Mein , Shu Yau , Shehla Mohammed , Laurent Guibaud , Mathias Gautel , Heinz Jungbluth	2017-09-01	-

研究热度

热点单位

排名	科研单位	文献
{{affIndex+1}}	{{aff.value}}	{{aff.size}}

目前还没有研究热点单位

热点人员

排名	研究人员	文献
{{authorIndex+1}}	{{author.value}}	{{author.size}}

目前还没有研究热点人员

© 2017 biocloud.net版权所有 ICP证：京10042835号