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57695 USP37

57695

USP37

ubiquitin specific peptidase 37

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin specific peptidase 37

研究结论

Date Results Publications
2020-09-26 13:07:00 The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency. 30858488
2020-08-22 15:28:00 USP37 promotes deubiquitination of HIF2alpha in kidney cancer. 32461361
2019-02-02 10:46:00 Findings reveal that USP37 is highly expressed in BCSCs and is correlated with poor prognosis in breast cancer patients. USP37 can regulate the stemness, cell invasion and EMT via Hh pathway, and decreased USP37 confers sensitivity to cisplatin in breast cancer cells. 30482232
2018-04-21 10:54:00 these findings reveal a role for REST-associated G9a and histone H3K9 methylation in the repression of USP37 expression in medulloblastoma. Reactivation of USP37 by G9a inhibition has the potential for therapeutic applications in REST-expressing medulloblastomas 28483947
2017-11-04 11:58:00 USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 in vivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin. 27296872

名称对应

Type IDs
Gene
UniProtKB-ID: UBP37_HUMAN, A0A024R416_HUMAN
UniprotKB: Q86T82, A0A024R416
UniParc: UPI0000160023, UPI00003D6571, UPI000198C716
EMBL: CH471063, AC073838, AL832645, BC144249, BC133007, BC144252, BC112901, BX538024, AB046814, AC012510, BC133009
Ensembl: ENSG00000135913
KO: hsa:57695
Nucleutide sequences
EMBL-CDS: AAY14887.1, AAI33010.1, AAI33008.1, AAI44250.1, CAD89955.1, AAI44253.1, CAD97970.1, EAW70621.1, BAB13420.1, AAI12902.1, EAW70622.1, EAW70623.1
Gene_ORFName: hCG_2043069
Ensembl_TRS: ENST00000415516, ENST00000454775, ENST00000418019, ENST00000258399
Protein sequencees
Ensembl_PRO: ENSP00000393662, ENSP00000396585, ENSP00000400902, ENSP00000258399
RefSeq: XP_005246778.1, XP_005246781.1, XP_011509843.1, XP_005246779.1, NP_065986.3, XP_011509840.1, XP_005246777.1, XP_016860066.1
Others
UniRef100: UniRef100_A0A024R416, UniRef100_Q86T82
UniRef90: UniRef90_Q86T82
UniRef50: UniRef50_Q86T82
UniGene: Hs.166068
CCDS: CCDS2418.1

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