UVSSA - UV stimulated scaffold protein A-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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57654 UVSSA

基因描述

Type	Description
Definition	UV stimulated scaffold protein A

研究结论

Date	Results	Publications
2021-02-02 13:25:00	USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.	31775559
2020-08-13 09:32:00	TCR is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified CSA-interaction motif (CIM); once recruited, CSA facilitates the association of UVSSA with stalled RNAPIIo; in addition, UVSSA is the key factor that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA	32355176
2019-12-14 12:03:00	Study reports nine UV-sensitive syndrome cases from two Pakistani families with a novel homozygous nonsense mutation, (c.1040 G > A [p.(Trp347*)]) in exon 6 of the UVSSA gene.	31421932
2019-11-30 11:08:00	FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates transcription-coupled nucleotide excision repair.	30715484
2019-01-12 12:00:00	UVSSA is mono-ubiquitinated in vitro. Lys(414) is the target of ubiquitination. Lys(414) was also modified by poly-ubiquitin chains in vivo. The substitution of Lys(414) by Arg of UVSSA inhibited its degradation and thereby suppressed the deficiency in transcription-coupled nucleotide excision repair.	29323787

名称对应

Type	IDs
Synonymous	KIAA1530, UVSS3
Gene	UniProtKB-ID: UVSSA_HUMAN, Q69YU2_HUMAN UniprotKB: Q2YD98, Q69YU2 UniParc: UPI0000073894, UPI0000401E3D, UPI00001C1E0C EMBL: AB040963, BC110331, AL390128, BC140901, AK292661, AC078852, AC118281, BC021930 Ensembl: ENSG00000163945 KO: hsa:57654
Nucleutide sequences	EMBL-CDS: AAI10332.1, AAI40902.1, BAF85350.1, AAH21930.1, BAA96054.1, CAH10662.1 Ensembl_TRS: ENST00000511216, ENST00000389851, ENST00000511563, ENST00000507531, ENST00000512728
Protein sequencees	Ensembl_PRO: ENSP00000423340, ENSP00000421741, ENSP00000425130, ENSP00000374501, ENSP00000427701 RefSeq: NP_065945.2, XP_016863986.1, XP_016863979.1, XP_016863989.1, NP_001304864.1, XP_016863981.1, XP_016863980.1, XP_016863984.1, XP_024309930.1, XP_016863982.1, XP_016863985.1, NP_001304863.1, XP_016863983.1, XP_016863988.1, XP_016863987.1
Others	UniRef100: UniRef100_Q2YD98, UniRef100_H0Y924 UniRef90: UniRef90_H0Y924, UniRef90_Q2YD98 UniRef50: UniRef50_Q2YD98, UniRef50_H0Y924 UniGene: Hs.380475 CCDS: CCDS33938.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
32355176	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II. Nat Commun Yana van der Weegen , Hadar Golan-Berman , Tycho E T Mevissen , Katja Apelt , RomÃ¡n GonzÃ¡lez-Prieto , Joachim Goedhart , Elisheva E Heilbrun , Alfred C O Vertegaal , Diana van den Heuvel , Johannes C Walter , Sheera Adar , Martijn S Luijsterburg	2020-04-30	-
32296183	A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G CotÃ© , Meaghan Daley , Steven Deimling , Alice Desbuleux , AmÃ©lie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , IstvÃ¡n A KovÃ¡cs , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood	2020-04-01	-
31775559	USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage. Cell Cycle Qianzheng Zhu , Nan Ding , Shengcai Wei , Ping Li , Gulzar Wani , Jinshan He , Altaf A Wani	2020-01-01	-
31421932	UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan. J. Dermatol. Sci. Ambreen Ijaz , Sabrina Wolf , Safur Rehman Mandukhail , Sulman Basit , Regina C Betz , Abdul Wali	2019-09-01	-
30715484	FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER. Nucleic Acids Res. Franziska Wienholz , Di Zhou , Yasemin Turkyilmaz , Petra Schwertman , Maria Tresini , Alex Pines , Marvin van Toorn , Karel Bezstarosti , Jeroen A A Demmers , Jurgen A Marteijn	2019-05-07	-
29531219	TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat Commun Alex Pines , Madelon Dijk , Matthew Makowski , Elisabeth M Meulenbroek , Mischa G Vrouwe , Yana van der Weegen , Marijke Baltissen , Pim J French , Martin E van Royen , Martijn S Luijsterburg , Leon H Mullenders , Michiel Vermeulen , Wim Vermeulen , Navraj S Pannu , Haico van Attikum	2018-03-12	-
29323787	Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7. FEBS J. Mitsuru Higa , Kiyoji Tanaka , Masafumi Saijo	2018-03-01	-
29395067	High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Mol. Cell Ji-Young Youn , Wade H Dunham , Seo Jung Hong , James D R Knight , Mikhail Bashkurov , Ginny I Chen , Halil Bagci , Bhavisha Rathod , Graham MacLeod , Simon W M Eng , StÃ©phane Angers , Quaid Morris , Marc Fabian , Jean-FranÃ§ois CÃ´tÃ© , Anne-Claude Gingras	2018-02-01	-
29069470	Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways. Nucleic Acids Res. Masahiko Okuda , Yuka Nakazawa , Chaowan Guo , Tomoo Ogi , Yoshifumi Nishimura	2017-12-15	-
28611215	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown	2017-06-27	-

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