| Type | Description |
|---|---|
| Definition | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:26:00 | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. | 32661198 |
| 2020-11-28 13:15:00 | PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. | 31636389 |
| 2020-05-23 11:26:00 | A multidomain assembly is key to the regulation of P-Rex1. | 31663027 |
| 2020-01-25 13:54:00 | PREX1 is a favorable variable of prognosis for breast cancer patients. | 31473760 |
| 2019-05-04 12:46:00 | GTPase-deficient G-ALPHA-qQL and Galpha13QL variants formed stable complexes with G protein beta gamma, impairing its interaction with P-REX1. | 30446620 |
| Type | IDs |
|---|---|
| Synonymous | P-REX1 |
| Gene |
UniProtKB-ID:
PREX1_HUMAN
UniprotKB:
Q8TCU6
UniParc:
UPI0001526386,
UPI0001526387,
UPI000013D375
EMBL:
AJ320261,
BC053616,
AL035106,
AL832913,
AL136579,
AB037836,
AL133342,
CH471077,
AL445192
Ensembl:
ENSG00000124126
KO:
hsa:57580
|
| Nucleutide sequences |
EMBL-CDS:
CAC86401.1,
AAH53616.1,
CAH10614.1,
EAW75685.1,
CAB66514.1,
EAW75684.1,
BAA92653.2
Ensembl_TRS:
ENST00000371941
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361009
RefSeq:
NP_065871.3,
XP_011527236.1
|
| Others |
UniRef100:
UniRef100_Q8TCU6
UniRef90:
UniRef90_Q8TCU6
UniRef50:
UniRef50_Q8TCU6
UniGene:
Hs.153310
CCDS:
CCDS13410.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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