| Type | Description |
|---|---|
| Definition | kelch like family member 42 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:25:00 | Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis. | 32071084 |
| 2010-01-21 00:00:00 | Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal | 19261606 |
| Type | IDs |
|---|---|
| Synonymous | Ctb9, KLHDC5 |
| Gene |
UniProtKB-ID:
KLH42_HUMAN,
B2RNT7_HUMAN,
F5H523_HUMAN
UniprotKB:
Q9P2K6,
B2RNT7,
F5H523
UniParc:
UPI0000185FB1,
UPI0000D4E920
EMBL:
BC028742,
BC108669,
AB037761,
BC137117,
AK095405,
AC009511,
BC137116,
CH471094
Ensembl:
ENSG00000087448
KO:
hsa:57542
|
| Nucleutide sequences |
EMBL-CDS:
AAI08670.1,
AAH28742.2,
BAA92578.1,
EAW96571.1,
AAI37118.1,
AAI37117.1,
BAG53048.1
Gene_ORFName:
hCG_1811238
Ensembl_TRS:
ENST00000381271,
ENST00000539176
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370671,
ENSP00000444748
RefSeq:
NP_065833.1,
XP_016875187.1
|
| Others |
UniRef100:
UniRef100_Q9P2K6,
UniRef100_F5H523
UniRef90:
UniRef90_Q9P2K6,
UniRef90_A0A2K5U231
UniRef50:
UniRef50_A0A2K5U231,
UniRef50_Q9P2K6
UniGene:
Hs.505104
CCDS:
CCDS31763.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 32071084 |
Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis. J Biol Chem Travis B Lear , Karina C Lockwood , Mads Larsen , Ferhan Tuncer , Jason R Kennerdell , Christina Morse , Eleanor Valenzi , Tracy Tabib , Michael J Jurczak , Daniel J Kass , John W Evankovich , Toren Finkel , Robert Lafyatis , Yuan Liu , Bill B Chen |
2020-03-27 | - |
| 31950832 |
IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. J Proteome Res Jingzi Zhang , Ruoyu Zhao , Clinton Yu , Christine L N Bryant , Kenneth Wu , Zhihong Liu , Yibing Ding , Yue Zhao , Bin Xue , Zhen-Qiang Pan , Chaojun Li , Lan Huang , Lei Fang |
2020-03-06 | - |
| 31615875 |
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. J. Cell Biol. Divya Achuthankutty , Roshan Singh Thakur , Peter Haahr , Saskia Hoffmann , Alexandros P Drainas , Anna H Bizard , Joachim Weischenfeldt , Ian D Hickson , Niels Mailand |
2019-12-02 | - |
| 28581483 |
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol. Daniel C Scott , Jared T Hammill , Jaeki Min , David Y Rhee , Michele Connelly , Vladislav O Sviderskiy , Deepak Bhasin , Yizhe Chen , Su-Sien Ong , Sergio C Chai , Asli N Goktug , Guochang Huang , Julie K Monda , Jonathan Low , Ho Shin Kim , Joao A Paulo , Joe R Cannon , Anang A Shelat , Taosheng Chen , Ian R Kelsall , Arno F Alpi , Vishwajeeth Pagala , Xusheng Wang , Junmin Peng , Bhuvanesh Singh , J Wade Harper , Brenda A Schulman , R Kip Guy |
2017-08-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 25416956 |
A proteome-scale map of the human interactome network. Cell Thomas Rolland , Murat TaÅan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal |
2014-11-20 | - |
| 25011449 |
Novel Cul3 binding proteins function to remodel E3 ligase complexes. BMC Cell Biol. Wananit Wimuttisuk , Mark West , Brittney Davidge , Kebing Yu , Arthur Salomon , Jeffrey D Singer |
2014-01-01 |
TRIM3,
LRR1,
RTN4RL1,
DMWD,
WDR90,
NLRP1,
TRIM32,
WDTC1,
FMOD,
LRRC8B,
ZBTB32,
POC1B,
WDR91,
PRAMEF8,
CIITA,
BTBD1,
BRWD1,
FBXW5,
PAK1IP1,
PHIP,
MYNN,
ERBIN,
LRFN2,
WDR35,
KLHL42,
LRRC7,
WDR48,
WDFY4,
PWP2,
GMCL1P1,
HIRA,
WDR77,
LRRK1,
WDR76,
SPOP,
UTP15,
CUL3,
DPH7,
COPB2,
WDR1
|
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|---|---|---|
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|---|---|---|
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