| Type | Description |
|---|---|
| Definition | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 15:24:00 | Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression. | 30827236 |
| 2020-04-18 10:23:00 | HACE1-YAP1 axis had an important part in the Colorectal cancer development and progression. | 30362561 |
| 2020-02-29 12:09:00 | Ectopic expression of HACE1 markedly inhibited anchorage-independent growth and cell motility of HACE1 osteosarcoma cell lines, HACE1 overexpression blocked osteosarcoma xenograft growth and dramatically reduced pulmonary metastases. These findings point to a potential tumor suppressor function for HACE1 in osteosarcoma. | 30622235 |
| 2020-02-01 13:31:00 | The present study demonstrates that KSHV infection induces the E3 ligase HACE1 protein to regulate KSHV-induced oxidative stress by promoting the activation of Nrf2 and nuclear translocation. | 30787155 |
| 2019-11-02 12:59:00 | our studies unveiled a suppressive role of HACE1 in tumor growth and migration of gastric cancer, and it might help to provide novel insights into the blockage of tumorigenesis and malignant process of early stage of gastric cancer. | 29673126 |
| Type | IDs |
|---|---|
| Synonymous | SPPRS |
| Gene |
UniProtKB-ID:
HACE1_HUMAN
UniprotKB:
Q8IYU2
UniParc:
UPI00001A75E6,
UPI0001AE7328,
UPI00001602DC,
UPI00000711B0
EMBL:
AL357315,
AK291760,
BC034982,
AL590402,
AK131207,
AB037741,
AL513472,
AK294164,
AL834202,
AK300314,
AK316091
Ensembl:
ENSG00000085382
KO:
hsa:57531
|
| Nucleutide sequences |
EMBL-CDS:
BAG62066.1,
BAA92558.1,
BAG54751.1,
AAH34982.1,
BAG57487.1,
BAF84449.1,
BAH14462.1,
CAD38890.1
Ensembl_TRS:
ENST00000262903,
ENST00000369125
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262903,
ENSP00000358121
RefSeq:
NP_001337486.1,
NP_001308013.1,
NP_001337483.1,
NP_001337488.1,
NP_001337484.1,
NP_001337489.1,
NP_001337485.1,
NP_001337487.1,
NP_001308012.1,
NP_065822.2,
NP_001308009.1
|
| Others |
UniRef100:
UniRef100_Q8IYU2
UniRef90:
UniRef90_Q8IYU2
UniRef50:
UniRef50_Q8IYU2
UniGene:
Hs.434340
CCDS:
CCDS5050.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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