| Type | Description |
|---|---|
| Definition | neuroligin 4 X-linked |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons. | 33268543 |
| 2020-09-12 16:05:00 | A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y. | 32243781 |
| 2019-11-02 11:44:00 | Neuroligin-4 is primarily expressed in cerebral cortex and localized to excitatory synapses. Overexpression of NLGN4 in human embryonic stem cell-derived neurons resulted in an increase in excitatory synapse numbers but a remarkable decrease in synaptic strength. The syndromic autism mutation NLGN4-R704C elicited more excitatory synapses but with increased functional synaptic transmission via a postsynaptic mechanism. | 31257103 |
| 2019-10-05 10:44:00 | the effects of rs1421589 within NRXN1, rs4844285 and rs11795613 within NLGN3, as well as rs5961397 within NLGX4X on Hirschsprung's disease phenotypes were also statistically significant. | 29622757 |
| 2019-07-06 10:41:00 | Steady-state fluorescence and microscale thermophoresis experiments allowed the authors to confirm the binding of some of mycotoxins to acetylcholinesterase and X-linked neuroligin 4, two proteins involved in synapse activity and, particularly for the second protein, neuronal plasticity and development. | 29123130 |
| Type | IDs |
|---|---|
| Synonymous | ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4 |
| Gene |
UniProtKB-ID:
NLGNX_HUMAN,
B3KP11_HUMAN,
A0A024RBV0_HUMAN,
A8K4S1_HUMAN
UniprotKB:
Q8N0W4,
B3KP11,
A0A024RBV0,
A8K4S1
UniParc:
UPI0000072EC5,
UPI0000371721,
UPI00015DA645,
UPI00004EAD1B
EMBL:
AK291036,
AK055471,
BC034018,
AF376803,
CH471074,
AB033086,
AY358562
Ensembl:
ENSG00000146938
KO:
hsa:57502
|
| Nucleutide sequences |
EMBL-CDS:
AAQ88925.1,
BAA86574.1,
AAH34018.1,
AAM46112.1,
BAG51523.1,
EAW98739.1,
EAW98741.1,
EAW98738.1,
BAF83725.1
Gene_ORFName:
UNQ365/PRO701,
hCG_1982900
Ensembl_TRS:
ENST00000381093,
ENST00000381095,
ENST00000275857,
ENST00000538097,
ENST00000381092
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370483,
ENSP00000370485,
ENSP00000275857,
ENSP00000439203,
ENSP00000370482
RefSeq:
NP_001269075.1,
XP_011543849.1,
XP_011543850.1,
XP_005274623.1,
NP_065793.1,
XP_016885180.1,
XP_016885182.1,
XP_016885181.1,
XP_005274622.1,
NP_001269074.1,
XP_005274621.1,
NP_851849.1,
XP_006724567.1
|
| Others |
UniRef100:
UniRef100_B3KP11,
UniRef100_Q8N0W4,
UniRef100_A8K4S1
UniRef90:
UniRef90_Q8N0W4
UniRef50:
UniRef50_Q8N0W4
UniGene:
Hs.21107
CCDS:
CCDS14126.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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