| Type | Description |
|---|---|
| Definition | KIAA1211 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:17:00 | Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4. | 33006362 |
| 2020-05-02 11:39:00 | The overall survival of small cell lung cancer patients carrying KIAA1211 mutation was significantly longer than those with wild-type KIAA1211. | 31699089 |
| 2019-04-27 10:18:00 | Datam indicate that cancer-related regulator of actin dynamics (CRAD) as frequently mutated or transcriptionally downregulated and as a tumour suppressor in colorectal cancer (CRC). | 30361697 |
| 2019-02-19 10:37:00 | CRAD (Cancer-related Regulator of Actin Dynamics, previously KIAA1211) binds to and inhibits capping proteins, which leads to actin polymerization. CRAD is ubiquitously expressed in epithelial cells and is required for the maintenance of epithelial cell integrity. Genetic ablation of this gene deregulates Wnt signaling and induces the development of tumors in mouse models. | 30361697 |
| Type | IDs |
|---|---|
| Synonymous | CRAD |
| Gene |
UniProtKB-ID:
CRACD_HUMAN
UniprotKB:
Q6ZU35
UniParc:
UPI0000237309
EMBL:
AC068620,
AB033037,
AL137336,
CH471057,
AL133028,
AK126014
Ensembl:
ENSG00000109265
KO:
hsa:57482
|
| Nucleutide sequences |
EMBL-CDS:
BAC86392.1,
EAX05481.1,
CAB61360.2,
CAB70699.1,
BAA86525.1
Ensembl_TRS:
ENST00000504228,
ENST00000264229
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264229,
ENSP00000423366
RefSeq:
XP_005265809.1,
NP_065773.1,
XP_024309926.1,
XP_006714108.1,
XP_016863963.1,
XP_005265812.1,
XP_011532699.1,
XP_005265813.1,
XP_024309927.1,
XP_016863962.1
|
| Others |
UniRef100:
UniRef100_Q6ZU35
UniRef90:
UniRef90_Q6ZU35
UniRef50:
UniRef50_Q6ZU35
UniGene:
Hs.596667
CCDS:
CCDS43230.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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