| Type | Description |
|---|---|
| Definition | CCR4-NOT transcription complex subunit 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 11:53:00 | Studied hepatic role in metabolic homeostasis of fibroblast growth factor 21(FGF21) and the "CCR4-NOT complex" (a multisubunit protein complex composed of "CCR4-NOT transcription complex subunit 6 like" (CNOT6L) and "CCR4-NOT transcription complex subunit 6" (CNOT6). Results show CNOT6L plays a major role in regulation FGF21 levels. | 30926667 |
| 2017-09-16 10:21:00 | The CNOT6 rs2453176 may be a new functional susceptible locus for lung cancer risk. | 27805284 |
| 2016-06-11 11:55:00 | miR-29c-3p promotes the senescence of Mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. | 26792405 |
| 2015-09-26 21:42:00 | These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. | 25944446 |
| 2011-07-23 11:16:00 | Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway. | 21233283 |
| Type | IDs |
|---|---|
| Synonymous | CCR4, Ccr4a |
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
NP_001357402.1,
XP_016865161.1,
NP_001357401.1,
NP_001357403.1,
XP_024301905.1,
XP_024301904.1,
XP_016865160.1
|
| Others |
UniGene:
Hs.608380
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31527615 |
Sci Data Giovanni Nassa , Giorgio Giurato , Annamaria Salvati , Valerio Gigantino , Giovanni Pecoraro , Jessica Lamberti , Francesca Rizzo , Tuula A Nyman , Roberta Tarallo , Alessandro Weisz |
2019-09-16 | - |
| 30926667 |
Proc Natl Acad Sci U S A Masahiro Morita , Nadeem Siddiqui , Sakie Katsumura , Christopher Rouya , Ola Larsson , Takeshi Nagashima , Bahareh Hekmatnejad , Akinori Takahashi , Hiroshi Kiyonari , Mengwei Zang , René St-Arnaud , Yuichi Oike , Vincent Giguère , Ivan Topisirovic , Mariko Okada-Hatakeyama , Tadashi Yamamoto , Nahum Sonenberg |
2019-04-16 | - |
| 30692204 |
A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes Dev. Csilla Keskeny , Tobias Raisch , Annamaria Sgromo , Cátia Igreja , Dipankar Bhandari , Oliver Weichenrieder , Elisa Izaurralde |
2019-02-01 | - |
| 29395067 |
Mol. Cell Ji-Young Youn , Wade H Dunham , Seo Jung Hong , James D R Knight , Mikhail Bashkurov , Ginny I Chen , Halil Bagci , Bhavisha Rathod , Graham MacLeod , Simon W M Eng , Stéphane Angers , Quaid Morris , Marc Fabian , Jean-François Côté , Anne-Claude Gingras |
2018-02-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 27805284 |
Mol. Carcinog. Fei Zhou , Yanru Wang , Hongliang Liu , Neal Ready , Younghun Han , Rayjean J Hung , Yonathan Brhane , John McLaughlin , Paul Brennan , Heike Bickeböller , Albert Rosenberger , Richard S Houlston , Neil Caporaso , Maria Teresa Landi , Irene Brüske , Angela Risch , Yuanqing Ye , Xifeng Wu , David C Christiani , Gary Goodman , Chu Chen , Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team , Christopher I Amos , Qingyi Wei |
2017-04-01 | - |
| 27173435 |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun Karsten Boldt , Jeroen van Reeuwijk , Qianhao Lu , Konstantinos Koutroumpas , Thanh-Minh T Nguyen , Yves Texier , Sylvia E C van Beersum , Nicola Horn , Jason R Willer , Dorus A Mans , Gerard Dougherty , Ideke J C Lamers , Karlien L M Coene , Heleen H Arts , Matthew J Betts , Tina Beyer , Emine Bolat , Christian Johannes Gloeckner , Khatera Haidari , Lisette Hetterschijt , Daniela Iaconis , Dagan Jenkins , Franziska Klose , Barbara Knapp , Brooke Latour , Stef J F Letteboer , Carlo L Marcelis , Dragana Mitic , Manuela Morleo , Machteld M Oud , Moniek Riemersma , Susan Rix , Paulien A Terhal , Grischa Toedt , Teunis J P van Dam , Erik de Vrieze , Yasmin Wissinger , Ka Man Wu , Gordana Apic , Philip L Beales , Oliver E Blacque , Toby J Gibson , Martijn A Huynen , Nicholas Katsanis , Hannie Kremer , Heymut Omran , Erwin van Wijk , Uwe Wolfrum , François Kepes , Erica E Davis , Brunella Franco , Rachel H Giles , Marius Ueffing , Robert B Russell , Ronald Roepman , UK10K Rare Diseases Group |
2016-05-13 | - |
| 26792405 |
Biochim Biophys Acta Jin Shang , Yuan Yao , Xin Fan , Lei Shangguan , Jie Li , Huan Liu , Yue Zhou |
2016-04-01 | - |
| 26972000 |
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Cell Rep Javier Rodriguez , Ruth Pilkington , Amaya Garcia Munoz , Lan K Nguyen , Nora Rauch , Susan Kennedy , Naser Monsefi , Ana Herrero , Cormac T Taylor , Alex von Kriegsheim |
2016-03-22 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
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