| Type | Description |
|---|---|
| Definition | protein phosphatase, Mg2+/Mn2+ dependent 1H |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:27:00 | PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins | 31663853 |
| 2020-03-07 12:11:00 | Lack of tumour PPM1H expression identifies a patient subgroup with a high relapse risk, and CRC cells with low expression of PPM1H activate cancer-association fibroblasts (CAFs) and inversely get promoted by CAFs. | 30988394 |
| 2017-03-11 11:40:00 | PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer | 27599670 |
| 2015-01-10 13:32:00 | PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. | 24732009 |
| 2012-11-24 10:38:00 | Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. | 22586611 |
| Type | IDs |
|---|---|
| Synonymous | ARHCL1, NERPP-2C, URCC2 |
| Gene |
UniProtKB-ID:
PPM1H_HUMAN
UniprotKB:
Q9ULR3
UniParc:
UPI00000557DD
EMBL:
BC157843,
AB084258,
CH471054,
AC025264,
AC048341,
AC023359,
AC078814,
AB032983
Ensembl:
ENSG00000111110
KO:
hsa:57460
|
| Nucleutide sequences |
EMBL-CDS:
BAG16181.1,
AAI57844.1,
EAW97112.1,
BAA86471.1
Ensembl_TRS:
ENST00000228705
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000228705
RefSeq:
XP_011536880.1,
XP_011536881.1,
XP_016875165.1,
NP_065751.1
|
| Others |
UniRef100:
UniRef100_Q9ULR3
UniRef90:
UniRef90_Q9ULR3
UniRef50:
UniRef50_Q9ULR3
UniGene:
Hs.435479
CCDS:
CCDS44934.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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