| Type | Description |
|---|---|
| Definition | pleckstrin homology and RhoGEF domain containing G5 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:44:00 | PLEKHG5 promoted glioma cell migration and invasion.The expression patterns of PLEKHG5 are related to the glioma patients' survival. | 31309383 |
| 2014-04-26 11:31:00 | Results indicate that different mutations in PLEKHG5 lead to clinically diverse outcomes Charcot-Marie-Tooth disease or lower motor neuron disease affecting the function of neurons and glial cells. | 23777631 |
| 2014-02-01 12:19:00 | Recruitment of Syx to the cell membrane, the selective activation of Dia1 signaling, coupled with the suppression of ROCK and actin reorganization, plays a key role in establishing cell polarity during directed cell migration. | 24126053 |
| 2014-01-04 12:28:00 | This study identifies compound heterozygous PLEKHG5 mutations as the cause of recessive intermediate Charcot-Marie-Tooth disease. | 23844677 |
| 2013-05-11 12:16:00 | a novel means of regulating junctional Syx localization and function by phosphorylation-induced 14-3-3 binding and further support the importance of Syx function in maintaining stable cell-cell contacts. | 23335514 |
| Type | IDs |
|---|---|
| Synonymous | CMTRIC, DSMA4, GEF720, Syx, Tech |
| Gene |
UniProtKB-ID:
PKHG5_HUMAN
UniprotKB:
O94827
UniParc:
UPI000206539E,
UPI000000D9EF,
UPI000006CF38,
UPI0000199544,
UPI000015F97E,
UPI000206539F,
UPI0000470BB3
EMBL:
CH471130,
AK294875,
AL591866,
AL158217,
AK299523,
AB097001,
AB018263,
BC015231,
AK096347,
BC042606,
AK131074
Ensembl:
ENSG00000171680
KO:
hsa:57449
|
| Nucleutide sequences |
EMBL-CDS:
EAW71547.1,
BAC77354.1,
BAH13058.1,
EAW71539.1,
BAG53269.1,
AAH15231.1,
BAA34440.2,
BAC85124.1,
BAH11909.1
Ensembl_TRS:
ENST00000340850,
ENST00000377728,
ENST00000377732,
ENST00000377725,
ENST00000535355,
ENST00000377748,
ENST00000537245,
ENST00000400915,
ENST00000400913
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000344570,
ENSP00000366961,
ENSP00000439625,
ENSP00000383706,
ENSP00000366977,
ENSP00000383704,
ENSP00000366954,
ENSP00000366957,
ENSP00000441445
RefSeq:
NP_001036128.2,
NP_001252521.2,
NP_001252523.1,
NP_001252522.1,
NP_001036129.1,
NP_001036130.1,
NP_941374.3,
NP_065682.2
|
| Others |
UniRef100:
UniRef100_O94827
UniRef90:
UniRef90_O94827
UniRef50:
UniRef50_O94827
UniGene:
Hs.284232,
Hs.619982
CCDS:
CCDS79.1,
CCDS57969.1,
CCDS57967.1,
CCDS41241.1,
CCDS57968.1,
CCDS41240.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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