| Type | Description |
|---|---|
| Definition | prostaglandin I2 synthase |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:24:00 | Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension. | 32236489 |
| 2019-04-27 12:23:00 | We identified an association between a PGIS variant and SAB risk that is modified by NSAIDs use during pregnancy and directly associated with increased levels of PGE metabolites. This suggests the potential use of genetic information to guide pharmaceutical intervention to prevent adverse pregnancy outcomes. | 28852049 |
| 2016-09-03 11:34:00 | In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA, 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression | 26130461 |
| 2015-06-27 13:18:00 | Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein. | 25623425 |
| 2015-03-21 13:17:00 | results indicate that PGIS expression was associated with radiotherapy efficiency | 25256272 |
| Type | IDs |
|---|---|
| Synonymous | CYP8, CYP8A1, PGIS, PTGI |
| Gene |
UniProtKB-ID:
PTGIS_HUMAN
UniprotKB:
Q16647
UniParc:
UPI00001328DF
EMBL:
AF297049,
D38145,
BC101809,
AF297051,
AL118525,
AF297050,
BC101811,
AF297052,
AF297048
Ensembl:
ENSG00000124212
KO:
hsa:5740
|
| Nucleutide sequences |
EMBL-CDS:
AAG31783.1,
BAA07343.1,
AAG31785.1,
AAG31782.1,
AAG31781.1,
AAI01812.1,
AAG31784.1,
AAI01810.1
Ensembl_TRS:
ENST00000244043
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000244043
RefSeq:
NP_000952.1
|
| Others |
UniRef100:
UniRef100_Q16647
UniRef90:
UniRef90_Q16647
UniRef50:
UniRef50_Q16647
UniGene:
Hs.302085
CCDS:
CCDS13419.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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