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57381 RHOJ

57381

RHOJ

ras homolog family member J

protein-coding

Homo sapiens

基因描述

Type Description
Definition ras homolog family member J

研究结论

Date Results Publications
2021-04-13 10:11:00 RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells. 32347571
2017-08-19 11:02:00 Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ signaling halts the growth of BRAF mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism. As up to 50% of BRAF mutant human melanomas express high levels of RhoJ, these studies nominate the RhoJ-BAD signaling network as a therapeutic vulnerability for fledgling BRAF mutant human tumor 28753606
2017-06-03 12:13:00 These results identify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus influence membrane association of the protein. 27660391
2016-06-11 11:56:00 FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site. 26299518
2015-04-25 12:55:00 RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility. 24928894

名称对应

Type IDs
Synonymous ARHJ, RASL7B, TC10B, TCL
Gene
UniProtKB-ID: RHOJ_HUMAN, A0A024R692_HUMAN, Q7Z513_HUMAN
UniprotKB: Q9H4E5, A0A024R692, Q7Z513
UniParc: UPI000013D1D8, UPI00001B3D51, UPI0000133894
EMBL: AK027278, AF309563, AF498977, AK027351, CH471061, BC062575, AJ276567, AF087862
Ensembl: ENSG00000126785
KO: hsa:57381
Nucleutide sequences
EMBL-CDS: BAB55013.1, BAB55055.1, AAM21124.1, AAL09440.1, CAC06611.1, AAH62575.1, EAW80824.1, EAW80822.1, AAP97172.1
Gene_ORFName: hCG_2028382
Ensembl_TRS: ENST00000316754
Protein sequencees
Ensembl_PRO: ENSP00000316729
RefSeq: XP_011535295.1, NP_065714.1, XP_006720277.1
Others
UniRef100: UniRef100_Q7Z513, UniRef100_Q9H4E5
UniRef90: UniRef90_Q9H4E5
UniRef50: UniRef50_Q9H4E5
UniGene: Hs.656339
CCDS: CCDS9757.1

全选

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