| Type | Description |
|---|---|
| Definition | isoprenylcysteine carboxyl methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:50:00 | Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses. | 32422978 |
| 2018-10-27 10:42:00 | Using cell culturing system, mouse model and patient samples, this work is the first to demonstrate the essential roles of Icmt in ovarian cancer via Ras signaling, particularly on its response to chemotherapy. | 29746868 |
| 2016-08-06 10:46:00 | simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML. | 26706195 |
| 2014-02-22 10:52:00 | ICMT deficiency precisely phenocopied Notch1 deficiency in the Pdx1-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt signaling. | 24216479 |
| 2010-01-21 00:00:00 | inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer. | 18502828 |
| Type | IDs |
|---|---|
| Synonymous | 1700008E11Rik, C80758, Gm13095, HSTE14, PPMT, STE14, pcCMT |
| Gene |
UniProtKB-ID:
ICMT_MOUSE,
Q3U4N2_MOUSE
UniprotKB:
Q9EQK7,
Q3U4N2
UniParc:
UPI00000274C5,
UPI00001C3210
EMBL:
AK154135,
AA022288,
BC110695,
AF209926,
AL611985
Ensembl:
ENSMUSG00000039662
KO:
mmu:57295
|
| Nucleutide sequences |
EMBL-CDS:
AAG48552.1,
AAI10696.1,
BAE32399.1
Ensembl_TRS:
ENSMUST00000048892
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000043390
RefSeq:
NP_598549.1
|
| Others |
UniRef100:
UniRef100_Q3U4N2,
UniRef100_Q9EQK7
UniRef90:
UniRef90_Q9EQK7
UniRef50:
UniRef50_Q9EQK7
UniGene:
Mm.277464
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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