| Type | Description |
|---|---|
| Definition | vav 3 oncogene |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:16:00 | Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro. | 32013053 |
| 2019-07-20 11:08:00 | Inactivation of Vav3 in vivo resulted in increased vascular leakage, highlighting its function as a key regulator of barrier stability. | 29858212 |
| 2019-05-18 11:00:00 | This study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3-dependent signaling pathway could help to improve myelin repair. | 30450647 |
| 2017-09-02 11:53:00 | we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis. | 26876204 |
| 2015-10-31 10:51:00 | Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis. | 25501893 |
| Type | IDs |
|---|---|
| Synonymous | A530094I06Rik, AA986410, Idd18.1 |
| Gene |
UniProtKB-ID:
VAV3_MOUSE
UniprotKB:
Q9R0C8
UniParc:
UPI0000027F77,
UPI000019B09B,
UPI00024B9D28
EMBL:
CR936848,
AK041249,
AK147053,
AL671857,
CR938729,
AL731716,
AL671987,
AF140280,
CR936838,
BC052739,
CR936849,
AF067816,
BC027242,
AK033253
Ensembl:
ENSMUSG00000033721
KO:
mmu:57257
|
| Nucleutide sequences |
EMBL-CDS:
BAE27637.1,
BAC28212.1,
AAF09171.1,
AAH27242.1,
BAC30879.2,
AAH52739.1,
AAF20330.2
Ensembl_TRS:
ENSMUST00000046864,
ENSMUST00000106576
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102186,
ENSMUSP00000036270
RefSeq:
NP_666251.1,
XP_036019089.1,
XP_006501883.1,
NP_065251.2,
NP_001365916.1
|
| Others |
UniRef100:
UniRef100_Q9R0C8
UniRef90:
UniRef90_Q9UKW4-4
UniRef50:
UniRef50_Q9UKW4
UniGene:
Mm.282257
CCDS:
CCDS17773.1,
CCDS59650.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员