| Type | Description |
|---|---|
| Definition | phosphoserine phosphatase |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:54:00 | a specific interaction between PSPH and IRS1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells, was identified. | 31446747 |
| 2019-12-21 11:26:00 | The results suggest that PSPH may act as a putative oncogene and a potential therapeutic target in NSCLC. | 30662358 |
| 2019-10-05 12:02:00 | three new high-resolution crystal structures of hPSP (1.5-2.0 A) in complexes with phosphoserine and with serine, which are the substrate and the product of the reaction, respectively, and in complex with a noncleavable substrate analogue (homocysteic acid) are presented. | 31205021 |
| 2017-08-19 11:20:00 | PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer. | 28476802 |
| 2015-12-19 10:23:00 | We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo | 25793315 |
| Type | IDs |
|---|---|
| Synonymous | PSP, PSPHD |
| Gene |
UniProtKB-ID:
SERB_HUMAN,
A0A024RDL3_HUMAN
UniprotKB:
P78330,
A0A024RDL3
UniParc:
UPI000013DA6D
EMBL:
BX537439,
BC063614,
AK315235,
CH471140,
Y10275
Ensembl:
ENSG00000146733
KO:
hsa:5723
|
| Nucleutide sequences |
EMBL-CDS:
CAD97681.1,
AAH63614.1,
BAG37662.1,
CAA71318.1,
EAX07968.1,
EAX07969.1
Gene_ORFName:
hCG_1811513
Ensembl_TRS:
ENST00000275605,
ENST00000437355,
ENST00000395471
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000275605,
ENSP00000378854,
ENSP00000401639
RefSeq:
NP_001357439.1,
NP_001357440.1,
NP_001357442.1,
NP_001357441.1,
NP_004568.2,
NP_001357449.1,
NP_001357447.1,
NP_001357448.1,
NP_001357435.1,
XP_016867958.1,
XP_016867956.1,
NP_001357432.1,
NP_001357446.1,
NP_001357444.1,
NP_001357450.1,
NP_001357436.1,
XP_016867957.1,
NP_001357443.1,
NP_001357437.1,
NP_001357438.1,
NP_001357434.1,
NP_001357445.1,
NP_001357451.1,
NP_001357433.1,
XP_006715824.1
|
| Others |
UniRef100:
UniRef100_P78330
UniRef90:
UniRef90_P78330
UniRef50:
UniRef50_P78330
UniGene:
Hs.512656
CCDS:
CCDS5522.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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