| Type | Description |
|---|---|
| Definition | THAP domain containing 11 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:42:00 | THAP11F80L exhibited a strong effect on association with the MMACHC promoter and led to a decrease in MMACHC gene transcription, suggesting that the THAP11F80L mutation is directly responsible for the observed cobalamin disorder | 31905202 |
| 2020-02-01 11:18:00 | THAP11 inhibited growth of esophageal cancer cells | 31969497 |
| 2018-07-21 11:29:00 | A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance. | 29269392 |
| 2018-01-13 12:01:00 | We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation. | 28449119 |
| 2018-01-06 10:04:00 | the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features. | 26975212 |
| Type | IDs |
|---|---|
| Synonymous | CTG-B43a, CTG-B45d, HRIHFB2206, RONIN |
| Gene |
UniProtKB-ID:
THA11_HUMAN
UniprotKB:
Q96EK4
UniParc:
UPI000013E8BD
EMBL:
EF036502,
AB015338,
AK289367,
BC012182
Ensembl:
ENSG00000168286
KO:
hsa:57215
|
| Nucleutide sequences |
EMBL-CDS:
AAH12182.1,
BAA34796.1,
BAF82056.1,
ABO65088.1
Gene_ORFName:
HRIHFB2206
Ensembl_TRS:
ENST00000303596
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000304689
RefSeq:
NP_065190.2
|
| Others |
UniRef100:
UniRef100_Q96EK4
UniRef90:
UniRef90_Q96EK4
UniRef50:
UniRef50_Q96EK4
UniGene:
Hs.632200
CCDS:
CCDS10847.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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