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57215 THAP11

57215

THAP11

THAP domain containing 11

protein-coding

Homo sapiens

基因描述

Type Description
Definition THAP domain containing 11

研究结论

Date Results Publications
2020-04-04 11:42:00 THAP11F80L exhibited a strong effect on association with the MMACHC promoter and led to a decrease in MMACHC gene transcription, suggesting that the THAP11F80L mutation is directly responsible for the observed cobalamin disorder 31905202
2020-02-01 11:18:00 THAP11 inhibited growth of esophageal cancer cells 31969497
2018-07-21 11:29:00 A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance. 29269392
2018-01-13 12:01:00 We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation. 28449119
2018-01-06 10:04:00 the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features. 26975212

名称对应

Type IDs
Synonymous CTG-B43a, CTG-B45d, HRIHFB2206, RONIN
Gene
UniProtKB-ID: THA11_HUMAN
UniprotKB: Q96EK4
UniParc: UPI000013E8BD
EMBL: EF036502, AB015338, AK289367, BC012182
Ensembl: ENSG00000168286
KO: hsa:57215
Nucleutide sequences
EMBL-CDS: AAH12182.1, BAA34796.1, BAF82056.1, ABO65088.1
Gene_ORFName: HRIHFB2206
Ensembl_TRS: ENST00000303596
Protein sequencees
Ensembl_PRO: ENSP00000304689
RefSeq: NP_065190.2
Others
UniRef100: UniRef100_Q96EK4
UniRef90: UniRef90_Q96EK4
UniRef50: UniRef50_Q96EK4
UniGene: Hs.632200
CCDS: CCDS10847.1

全选

研究热度
发表文献
研究结论
热点单位
排名 科研单位 文献
1

Beijing Institute of Radiation Medicine

4
2

University of Toronto

3
3

McGill University

3
4

Dana-Farber Cancer Institute

2
5

Institute for Research in Biomedicine (IRB Barcelona)

2
热点人员
排名 研究人员 文献
1

Fana Gebreab

3
2

Stanley Tam

3
3

David E Hill

3
4

Amélie Dricot

3
5

Marc Vidal

3
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