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57107 PDSS2

57107

PDSS2

decaprenyl diphosphate synthase subunit 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition decaprenyl diphosphate synthase subunit 2

研究结论

Date Results Publications
2020-04-25 11:24:00 Study identified the promoter region of the PDSS2 gene for the first time and demonstrated that Sp1 transcription factor could directly regulate the transcription of PDSS2. Also, the expression of Sp1 and PDSS2 are negatively correlated, and higher Sp1 expression with low PDSS2 expression is significantly associated with poor prognosis in lung cancer. 31783675
2019-09-28 10:22:00 Knockdown of PDSS2 induced chromosomal instability in the MIHA immortalized human liver cell line. Furthermore, knockdown of PDSS2 in MIHA induced malignant transformation. Overall, our findings indicate that PDSS2 deficiency might be a novel driving factor in hepatocellular carcinoma (HCC) development 29967258
2018-05-26 10:51:00 Results indicate PDSS2 gene which regulates coffee consumption by regulating the expression of the genes linked to caffeine metabolism. 27561104
2015-12-05 11:07:00 PDSS2 encodes a putative tumor suppressor, and its expression is regulated by hypermethylation of its promoter in gastric cancer cells. 25330808
2015-10-17 11:44:00 Decreased PDSS2 expression is an unfavorable prognostic factor for hepatocellular carcinoma, and PDSS2 has potent anticancer activity in HCC tissues and HepG2 cells. 25780306

名称对应

Type IDs
Synonymous C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1
Gene
UniProtKB-ID: DLP1_HUMAN, B4DKU5_HUMAN, B4DWD3_HUMAN
UniprotKB: Q86YH6, B4DKU5, B4DWD3
UniParc: UPI000013E3B4, UPI00017A82D9, UPI00017A750A, UPI000020E031
EMBL: AL355586, AB210839, AK301480, AL591516, BC029491, AF254956, BC039906, AL590489, AL121957, AK296717
Ensembl: ENSG00000164494
KO: hsa:57107
Nucleutide sequences
EMBL-CDS: BAE48217.1, AAH29491.1, AAF97788.1, AAH39906.1, BAG59307.1, BAG62995.1
Ensembl_TRS: ENST00000369031, ENST00000369037
Protein sequencees
Ensembl_PRO: ENSP00000358027, ENSP00000358033
RefSeq: XP_011534264.1, XP_011534265.1, XP_011534260.1, XP_011534261.1, XP_016866571.1, XP_011534258.1, XP_011534259.1, XP_011534262.1, XP_011534263.1, NP_065114.3
Others
UniRef100: UniRef100_Q86YH6, UniRef100_B4DKU5
UniRef90: UniRef90_Q86YH6, UniRef90_F7B491
UniRef50: UniRef50_A0A3Q2TUP7, UniRef50_Q86YH6
UniGene: Hs.745008
CCDS: CCDS5059.1

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