| Type | Description |
|---|---|
| Definition | apoptosis and caspase activation inhibitor |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:43:00 | MiR-30b-5p expression was found to be significantly upregulated in hypoxic cardiomyocytes, AC16 cells. The in vitro experiments showed that downregulation of miR-30b-5p effectively alleviated hypoxia-induced cardiomyocyte injury. Aven is a potential target gene of miR-30b-5p and its downregulation could partially reverse the influence of miR-30b-5p knockdown on AC16 cells under hypoxia. | 31768184 |
| 2019-09-21 11:47:00 | Expression of granulosa cell microRNAs, AVEN and ATRX are associated with human blastocyst development. | 29693772 |
| 2017-08-05 10:11:00 | AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells | 27388765 |
| 2016-06-11 12:10:00 | The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. | 26267306 |
| 2016-03-26 11:31:00 | the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents. | 25573060 |
| Type | IDs |
|---|---|
| Synonymous | PDCD12 |
| Gene |
UniProtKB-ID:
AVEN_HUMAN
UniprotKB:
Q9NQS1
UniParc:
UPI000012666A
EMBL:
AF283508,
BC063533,
BC010488
Ensembl:
ENSG00000169857
KO:
hsa:57099
|
| Nucleutide sequences |
EMBL-CDS:
AAH10488.1,
AAH63533.1,
AAF91470.1
Ensembl_TRS:
ENST00000306730
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000306822
RefSeq:
NP_065104.1,
XP_011520120.1,
XP_011520121.1,
XP_024305767.1,
XP_011520122.1
|
| Others |
UniRef100:
UniRef100_Q9NQS1
UniRef90:
UniRef90_Q9NQS1
UniRef50:
UniRef50_Q9NQS1
UniGene:
Hs.555966
CCDS:
CCDS10030.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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