| Type | Description |
|---|---|
| Definition | kinetochore scaffold 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:53:00 | CASC5 is a potential tumour driving gene in lung adenocarcinoma. | 32283571 |
| 2021-02-20 13:34:00 | [CASC5 Gene Expression Changes Correlate with in Leukemia]. | 33566033 |
| 2020-01-11 12:17:00 | KNL1 protein expression was also significantly associated with poorer survival. Moreover, there was a significant correlation between KNL1 and BUB1 in colorectal cancer tissues. KNL1 plays an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach in patients with colorectal cancer. | 31315522 |
| 2019-12-21 11:23:00 | KNL1 mutation is associated with Microcephaly. | 30304678 |
| 2019-09-21 10:06:00 | Data show how KNL1 binds both PP1 and microtubules. Unexpectedly, PP1 and microtubules bind KNL1 via overlapping binding sites. Co-sedimentation assays unequivocally demonstrated that microtubules and PP1 binding to KNL1 is mutually exclusive, with preferential formation of the KNL1:PP1 holoenzyme in the presence of PP1. | 30100357 |
| Type | IDs |
|---|---|
| Synonymous | AF15Q14, CASC5, CT29, D40, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105 |
| Gene |
UniProtKB-ID:
KNL1_HUMAN
UniprotKB:
Q8NG31
UniParc:
UPI0000E59BD2,
UPI00018E1807,
UPI0000E59BD1,
UPI0000E59BD3
EMBL:
AC022405,
AF173994,
AF461041,
AB046790,
AF248041,
AB022190
Ensembl:
ENSG00000137812
KO:
hsa:57082
|
| Nucleutide sequences |
EMBL-CDS:
BAB13396.1,
BAC05691.1,
AAM45143.1,
AAF97513.1,
AAL67803.1
Ensembl_TRS:
ENST00000346991,
ENST00000399668
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382576,
ENSP00000335463
RefSeq:
NP_653091.3,
XP_016877921.1,
NP_733468.3
|
| Others |
UniRef100:
UniRef100_Q8NG31
UniRef90:
UniRef90_Q8NG31
UniRef50:
UniRef50_Q8NG31
UniGene:
Hs.181855
CCDS:
CCDS42024.1,
CCDS42023.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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