| Type | Description |
|---|---|
| Definition | twisted gastrulation BMP signaling modulator 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-03 10:24:00 | Internal cleavage and synergy with TWSG1 enhance BMP-4 inhibition by BMPER. | 30125619 |
| 2018-06-23 11:49:00 | Findings indicate that twisted gastrulation homolog 1 (TWSG1) maybe serves as a tumor suppressor gene in gastric cancer and potential biomarker or therapeutic target for the diagnosis and treatment of gastric cancer. | 29756996 |
| 2018-02-24 11:52:00 | Tsg functions as a BMP-agonist by inducing conformational change in chordin making it more susceptible to tolloid cleavage and as a BMP-antagonist either independently or via a chordin-mediated mechanism. | 26829466 |
| 2016-08-27 12:10:00 | Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. | 26517884 |
| 2013-11-30 11:58:00 | these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis. | 23641068 |
| Type | IDs |
|---|---|
| Synonymous | TSG |
| Gene |
UniProtKB-ID:
TWSG1_HUMAN
UniprotKB:
Q9GZX9
UniParc:
UPI0001637B29,
UPI0000071AF6
EMBL:
CH471113,
AP001033,
AK027629,
AJ297391,
AK075550,
AF196834,
AF294628,
BC020490,
AK315751
Ensembl:
ENSG00000128791
KO:
hsa:57045
|
| Nucleutide sequences |
EMBL-CDS:
CAC05581.1,
AAG10076.1,
EAX01606.1,
AAH20490.1,
BAB55246.1,
EAX01607.1,
BAC11693.1,
AAG43468.1,
BAG38105.1
Gene_ORFName:
PSEC0250
Ensembl_TRS:
ENST00000583147,
ENST00000262120
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262120,
ENSP00000463331
RefSeq:
NP_065699.1
|
| Others |
UniRef100:
UniRef100_Q9GZX9
UniRef90:
UniRef90_Q9GZX9
UniRef50:
UniRef50_Q9GZX9
UniGene:
Hs.514685
CCDS:
CCDS11844.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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