| Type | Description |
|---|---|
| Definition | pyridoxal (pyridoxine, vitamin B6) phosphatase |
| Date | Results | Publications |
|---|---|---|
| 2020-08-12 10:57:00 | PLPP/CIN deletion inhibited NEDD4-2 ubiquitination, and diminished the responsiveness of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor by facilitating NEDD4-2-mediated ubiquitination of GluA1 subunit under physiological condition. PLPP/CIN overexpression reversed these effects. These PLPP/CIN-mediated processes were required for the increased seizure severity and its progression in response to kaini... | 31320629 |
| 2018-05-26 11:56:00 | Results provided novel evidence that PLPP is involved in controlling dendritic spine as well as synaptic plasticity. It showed also for the first time the role of PLPP in GluN functionality via regulation of GluN2A interaction with postsynaptic proteins. These findings suggest that PLPP/CIN may play an important role in information storage and recall capacity, which manifests as a learning memory. | 27212638 |
| 2014-04-12 12:20:00 | Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination. | 24338687 |
| 2014-04-12 12:20:00 | Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities. | 24338473 |
| 2010-01-21 00:00:00 | analysis of pyridoxal phosphatase cloning, expression and tissue distribution | 14522954 |
| Type | IDs |
|---|---|
| Synonymous | 1600027H05Rik, AB041662, PLPP |
| Gene |
UniProtKB-ID:
PLPP_MOUSE,
Q6IS27_MOUSE
UniprotKB:
P60487,
Q6IS27
UniParc:
UPI0000376A1B,
UPI00001938E1
EMBL:
AY366300,
BC069982,
BC058388
Ensembl:
ENSMUSG00000116165
KO:
mmu:57028
|
| Nucleutide sequences |
EMBL-CDS:
AAH58388.1,
AAR12209.1,
AAH69982.1
Ensembl_TRS:
ENSMUST00000089378
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000086796
RefSeq:
NP_064667.2
|
| Others |
UniRef100:
UniRef100_P60487
UniRef90:
UniRef90_P60487
UniRef50:
UniRef50_Q96GD0
UniGene:
Mm.263169
CCDS:
CCDS27627.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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